lin-Benzoinosin | 60189-63-1

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• 英文名称: lin-Benzoinosin
• 英文别名: 3-β-D-ribofuranosyl-3,7-dihydro-imidazo[4,5-g]quinazolin-8-one；3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7H-imidazo[4,5-g]quinazolin-8-one
• CAS: 60189-63-1
• 化学式: C₁₄H₁₄N₄O₅
• 分子量: 318.289
• InChiKey: OMWMTNVDORQJPF-HKUMRIAESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  129
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• [EN] UNUSUAL NUCLEOSIDE LIBRARIES, COMPOUNDS, AND PREFERRED USES AS ANTIVIRAL AND ANTICANCER AGENTS<br/>[FR] BANQUES DE NUCLEOSIDES ET COMPOSES RARES, ET UTILISATIONS PREFEREES COMME AGENTS ANTICANCEREUX ET ANTIVIRAUX
  申请人：RIBAPHARM INC

  公开号：WO2003051898A1

  公开（公告）日：2003-06-26

  Nucleoside analog libraries are prepared in a combinatorial library approach. Particularly preferred compounds and libraries include nucleoside analogs in which the heterocyclic base is coupled to the sugar via a non-carbon atom, nucleoside analogs with a tricyclic heterocyclic base that includes benzimidazole, and nucleoside analogs in which a C2'-substituent is covalently bound to the sugar via a carbon atom. Contemplated nucleosides may be useful in treatment of various conditions, and particularly viral infections and neoplastic diseases.