tert-butyl 3-(4-methoxyphenyl)-2-oxopropylcarbamate | 955036-36-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: tert-butyl 3-(4-methoxyphenyl)-2-oxopropylcarbamate
• 英文别名: tert-butyl N-[3-(4-methoxyphenyl)-2-oxopropyl]carbamate
• CAS: 955036-36-9
• 化学式: C₁₅H₂₁NO₄
• 分子量: 279.336
• InChiKey: CECFRZLZMWFWQX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲氧基苯乙酸 在 copper (I) acetate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 14.5h， 生成 tert-butyl 3-(4-methoxyphenyl)-2-oxopropylcarbamate
  参考文献：
  名称：

  Synthesis of 2-Aminoazoles from Thioesters via α-Heterosubstituted Ketones by Copper-Mediated Cross-Coupling

  摘要：

  Facile synthesis of a variety of alpha-heterosubstituted ketones under mild conditions was achieved by copper-mediated cross-coupling of thioesters with functionalized organostannanes. Application of this coupling methodology provided a concise pathway for the conversion of carboxylic acids to 2-aminoimidazoles, 2-aminothiazoles, and 2-aminooxazoles via thioesters in practical yields.

  DOI：

  10.1021/acs.joc.5b01558

文献信息

• Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
  申请人：Wang Yanjun Eric

  公开号：US20070293548A1

  公开（公告）日：2007-12-20

  Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

  提供了用于治疗炎症性疾病和免疫紊乱的组合物及使用组合物的方法。公开了一种烯丙胺化合物，它们是半胱氨酸敏感胺氧化酶（SSAO）和/或血管粘附蛋白1（VAP-1）的抑制剂。这些化合物在抑制炎症和炎症反应方面具有治疗效用，并可用于治疗多发性硬化症和中风等多种疾病。
• INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES
  申请人：WANG Eric Yanjun

  公开号：US20110269811A1

  公开（公告）日：2011-11-03

  Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-1). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.

  提供了治疗炎症性疾病和免疫紊乱的组合物和使用组合物的方法。披露了抑制半胱氨酸敏感胺氧化酶（SSAO）和/或血管黏附蛋白1（VAP-1）的丙烯氨基化合物。这些化合物在抑制炎症和炎症反应以及治疗多种疾病，包括多发性硬化和中风方面具有治疗效用。
• [EN] INHIBITORS OF SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) AND VAP-1 MEDIATED ADHESION USEFUL FOR TREATMENT AND PREVENTION OF DISEASES<br/>[FR] INHIBITEURS D'ADHÉRENCE MÉDIÉE PAR L'AMINE OXYDASE SENSIBLE AUX SEMI-CARBAZIDES (SSAO) ET LA VAP-1 UTILISÉS DANS LE TRAITEMENT ET LA PRÉVENTION DE MALADIES
  申请人：JOLLA PHARMA

  公开号：WO2007120528A2

  公开（公告）日：2007-10-25

  [EN] Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascular adhesion protein 1 (VAP-I). The compounds have therapeutic utility in suppressing inflammation and inflammatory responses, and in treatment of several disorders, including multiple sclerosis and stroke.
  [FR] L'invention concerne des compositions et des méthodes d'utilisation des compositions dans le traitement de maladies inflammatoires et de troubles immuns. L'invention concerne également des composés allylamino qui constituent des inhibiteurs de l'amine oxydase sensible aux semi-carbazides (SSAO) et/ou de la protéine 1 d'adhérence vasculaire (VAP-I). Lesdits composés sont utilisés d'un point de vue thérapeutique dans la suppression de l'inflammation et des réponses inflammatoires, et dans le traitement de divers troubles, y compris la sclérose en plaques et l'accident vasculaire cérébral.