2-amino-5-(hexyloxy)-5-oxopentanoic acid | 14015-78-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-amino-5-(hexyloxy)-5-oxopentanoic acid
• 英文别名: 2-Amino-5-hexoxy-5-oxopentanoic acid
• CAS: 14015-78-2
• 化学式: C₁₁H₂₁NO₄
• 分子量: 231.292
• InChiKey: UVSKNOPLQXMUSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  16
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  89.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-amino-5-(hexyloxy)-5-oxopentanoic acid 在 三光气 作用下， 生成 Hexyl 3-(2,5-dioxo-1,3-oxazolidin-4-yl)propanoate
  参考文献：
  名称：

  The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers

  摘要：

  The solid state and melt nanoscale structures of a series of poly(ethylene glycol)-block-poly(gamma-alkyl-L-glutamate)s (PEG-b-PALG) copolymers bearing different alkyl side groups, i.e., n-butyl, n-hexyl, n-octyl, and n-dodecyl, have been investigated in the present work. An interesting effect of alkyl side groups on the secondary conformation of polypeptide block, crystallization of PEG segments and morphology of the copolymers was observed. With increasing the length of alkyl side groups or raising the temperature, the predominant secondary structure gradually changed from alpha-helix to beta-sheet conformation. Differential scanning calorimetry, wide-angle X-ray diffraction analysis and polarized optical microscopy indicated that the crystallization and morphology of PEG segments were markedly restricted by the polypeptide block. Therefore, the alkyl side groups not only exhibited significant influence on the conformation of polypeptide block, but also affected the crystallization of PEG segments. The secondary structure, crystallization and spherulite morphology of these synthetic biomaterials, which were significantly influenced by alkyl side groups, may play an important role in their physicochemical properties, such as self-assembly, as well as in some biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2013.02.038
• 作为产物：
  描述：

  DL-谷氨酸 、 正己醇 在 硫酸 作用下， 生成 2-amino-5-(hexyloxy)-5-oxopentanoic acid
  参考文献：
  名称：

  The effect of alkyl side groups on the secondary structure and crystallization of poly(ethylene glycol)-block-polypeptide copolymers

  摘要：

  The solid state and melt nanoscale structures of a series of poly(ethylene glycol)-block-poly(gamma-alkyl-L-glutamate)s (PEG-b-PALG) copolymers bearing different alkyl side groups, i.e., n-butyl, n-hexyl, n-octyl, and n-dodecyl, have been investigated in the present work. An interesting effect of alkyl side groups on the secondary conformation of polypeptide block, crystallization of PEG segments and morphology of the copolymers was observed. With increasing the length of alkyl side groups or raising the temperature, the predominant secondary structure gradually changed from alpha-helix to beta-sheet conformation. Differential scanning calorimetry, wide-angle X-ray diffraction analysis and polarized optical microscopy indicated that the crystallization and morphology of PEG segments were markedly restricted by the polypeptide block. Therefore, the alkyl side groups not only exhibited significant influence on the conformation of polypeptide block, but also affected the crystallization of PEG segments. The secondary structure, crystallization and spherulite morphology of these synthetic biomaterials, which were significantly influenced by alkyl side groups, may play an important role in their physicochemical properties, such as self-assembly, as well as in some biomedical applications. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.polymer.2013.02.038

文献信息

• GLUTAMATE DERIVATIVES FOR TOPICAL USE AS IMMUNOMODULATORY ACTIVE INGREDIENT
  申请人：PIERRE FABRE DERMO-COSMETIQUE

  公开号：US20160060208A1

  公开（公告）日：2016-03-03

  The present invention relates to L-glutamate-derived compounds of general formula (1) in which the R radical is a linear or branched C 5 to C 2 alkyl group, .—or the benzyl radical, .—or the phenethyl radical, for topical use as a medicament (or as a dermatological active ingredient) intended for the treatment and/or prevention of inflammatory dermatoses.

  本发明涉及一般式（1）中的L-谷氨酸衍生化合物，其中R基团是线性或支链的C5至C2烷基基团，苯甲基基团或苯乙基基团，用于局部使用作为药物（或皮肤科活性成分），用于治疗和/或预防炎症性皮肤病。
• DERIVES DE GLUTAMATE POUR LEUR UTILISATION TOPIQUE EN TANT QUE PRINCIPE ACTIF IMMUNOMODULATEUR
  申请人：Pierre Fabre Dermo-Cosmétique

  公开号：EP2934506B1

  公开（公告）日：2018-01-17
• US9493401B2
  申请人：——

  公开号：US9493401B2

  公开（公告）日：2016-11-15