C^α-methyl-D,L-prenylglycinamide | 364784-16-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: C^α-methyl-D,L-prenylglycinamide
• 英文别名: 2-Amino-2,5-dimethylhex-4-enamide
• CAS: 364784-16-7
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: CFKPCPZYXBSXID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  C^α-methyl-D,L-prenylglycinamide 在 Mycobacterium neoaurum ATCC 25795 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 C^α-methyl-D-prenylglycinamide 、 C^α-methyl-L-prenylglycinamide 、 C^α-methyl-L-prenylglycine
  参考文献：
  名称：

  Enantiopure Cα-tetrasubstituted α-amino acids. Chemo-enzymatic synthesis and application to turn-forming peptides

  摘要：

  By a chemo-enzymatic approach we carried out a large-scale synthesis of four enantiopure, sterically constrained, C-alpha-tetra-substituted alpha -amino acids, all characterized by a sidechain (CCdelta)-C-gamma double bond. By using one of them (L-Mag), we prepared an N-alpha-protected tetrapeptide benzylamide which was shown to adopt a beta -turn conformation and to efficiently undergo ring-closing olefin metathesis. (C) 2001 Elsevier Science Led. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00548-8
• 作为产物：
  描述：

  2,5-Dimethyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-hex-4-enoic acid amide 在 盐酸 、 水 作用下， 生成 C^α-methyl-D,L-prenylglycinamide
  参考文献：
  名称：

  Enantiopure Cα-tetrasubstituted α-amino acids. Chemo-enzymatic synthesis and application to turn-forming peptides

  摘要：

  By a chemo-enzymatic approach we carried out a large-scale synthesis of four enantiopure, sterically constrained, C-alpha-tetra-substituted alpha -amino acids, all characterized by a sidechain (CCdelta)-C-gamma double bond. By using one of them (L-Mag), we prepared an N-alpha-protected tetrapeptide benzylamide which was shown to adopt a beta -turn conformation and to efficiently undergo ring-closing olefin metathesis. (C) 2001 Elsevier Science Led. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00548-8