| 1146320-18-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• CAS: 1146320-18-4
• 化学式: C₁₉H₂₀N₂O₄
• 分子量: 340.379
• InChiKey: AHDSAVZVLNUEMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  547.3±50.0 °C(predicted)
• 密度：
  1.20±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 sodium hydroxide 、 水 、 盐酸 作用下， 以 丙酮 、 水 为溶剂， 反应 3.0h， 以100%的产率得到4'-(3,4-dimethoxyphenyl)-1'H-1,3'-bipyrrole-2'-carboxylic acid
  参考文献：
  名称：

  Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1–5, GSK-3) inhibitors

  摘要：

  We herein describe the synthesis of novel dipyrrolo- and furopyrrolopyrazinones related to highly cytotoxic tripentones and to their oximes. The synthetic pathway involved in particular a Curtius rearrangement and a subsequent cyclisation into the title pyrazinones. The biological evaluation towards various cyclin-dependent kinases (CDKs1-5, GSK-3) highlighted a weak inhibitory activity for the oximes whose SAR was studied by a molecular modeling study. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.05.011
• 作为产物：
  描述：

  2,5-二甲氧基四氢呋喃 、 ethyl 3-amino-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylate 在 4-氯吡啶盐酸盐 作用下， 以 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1–5, GSK-3) inhibitors

  摘要：

  We herein describe the synthesis of novel dipyrrolo- and furopyrrolopyrazinones related to highly cytotoxic tripentones and to their oximes. The synthetic pathway involved in particular a Curtius rearrangement and a subsequent cyclisation into the title pyrazinones. The biological evaluation towards various cyclin-dependent kinases (CDKs1-5, GSK-3) highlighted a weak inhibitory activity for the oximes whose SAR was studied by a molecular modeling study. (c) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2008.05.011