2-苯基氨基-3-氨基-6-氯吡啶 | 6604-76-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-苯基氨基-3-氨基-6-氯吡啶
• 英文名称: 2-phenylamino-3-amino-6-chloropyridine
• 英文别名: 6-chloro-N2-phenylpyridine-2,3-diamine；3-Amino-2-anilino-6-chlorpyridin；6-chloro-2-N-phenylpyridine-2,3-diamine
• CAS: 6604-76-8
• 化学式: C₁₁H₁₀ClN₃
• 分子量: 219.673
• InChiKey: LPYNOJYQHSVMLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-苯基氨基-3-氨基-6-氯吡啶 在 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 生成 5-Chlor-3-phenyltriazolo<4,5-b>pyridin
  参考文献：
  名称：

  Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

  摘要：

  PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.130
• 作为产物：
  描述：

  2,6-二氯-3-硝基吡啶 在 氢气 、 碳酸氢钠 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 生成 2-苯基氨基-3-氨基-6-氯吡啶
  参考文献：
  名称：

  Hit to lead evaluation of 1,2,3-triazolo[4,5-b]pyridines as PIM kinase inhibitors

  摘要：

  PIM kinases have become targets of interest due to their association with biochemical mechanisms affecting survival, proliferation and cytokine production. 1,2,3-Triazolo[4,5-b]pyridines were identified as PIM inhibitors applying a scaffold hopping approach. Initial exploration around this scaffold and X-ray crystallographic data are hereby described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.130

文献信息

• [EN] IMIDAZOPYRIDINE DERIVATIVES AS PI3K INHIBITORS<br/>[FR] DÉRIVÉS D'IMIDAZOPYRIDINE EN TANT QU'INHIBITEURS DE PI3K
  申请人：ALMIRALL SA

  公开号：WO2012146667A1

  公开（公告）日：2012-11-01

  New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Phosphoinositide 3-Kinases (PI3Ks).

  揭示了具有化学结构公式（I）的新咪唑吡啶衍生物；以及它们的制备方法，包含它们的药物组合物和它们作为磷脂酰肌醇3-激酶（PI3Ks）抑制剂在治疗中的用途。
• Bianchi; Butti; Rossi, European Journal of Medicinal Chemistry, 1983, vol. 18, # 6, p. 501 - 506
  作者：Bianchi、Butti、Rossi、et al.

  DOI：——

  日期：——