N-(methanesulfonyl)-16-(m-methoxyphenoxy)-ω-tetranor-PGE₂-carboxamide | 79124-68-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(methanesulfonyl)-16-(m-methoxyphenoxy)-ω-tetranor-PGE₂-carboxamide
• CAS: 79124-68-8
• 化学式: C₂₄H₃₃NO₈S
• 分子量: 495.594
• InChiKey: HHNDNDJEVMEMLC-OHQYJMMLSA-N

反应信息

• 作为产物：
  描述：

  在 溶剂黄146 作用下， 反应 14.0h， 生成 N-(methanesulfonyl)-16-(m-methoxyphenoxy)-ω-tetranor-PGE₂-carboxamide
  参考文献：
  名称：

  N-(Methanesulfonyl)-16-phenoxyprostaglandin carboxamides: tissue-selective, uterine stimulants

  摘要：

  In an effort to develop tissue-selective prostaglandin analogues resistant to the metabolic inactivating pathways of the natural materials, hybrid compounds modified both at C-1 with a sulfonimide moiety and in the n-amylcarbinol side chain with substituted phenoxy groups were synthesized and evaluated in a variety of in vitro models. Several of these analogues exhibited potent, tissue-selective, uterine stimulant activity, a finding subsequently confirmed in clinical studies with one member of this series, N-(methanesulfonyl)-16-phenoxy-omega-tetranor-PGE2-carboxamide (CP-34089/ZK-57671, sulprostone).

  DOI：

  10.1021/jm00143a018