(2,6-Dimethyloxan-4-yl)methanamine | 1555719-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (2,6-Dimethyloxan-4-yl)methanamine
• CAS: 1555719-81-7
• 化学式: C₈H₁₇NO
• mdl: MFCD24252512
• 分子量: 143.229
• InChiKey: PXKYQRMDUIMEAZ-UHFFFAOYSA-N

物化性质

• 沸点：
  203.5±13.0 °C(Predicted)
• 密度：
  0.882±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-chloro-N-(2,4-dimethoxybenzyl)-2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide 、 (2,6-Dimethyloxan-4-yl)methanamine 在 alkali carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation

  摘要：

  Since zwitterionic benzenesulfonamide Na(v)1.7 inhibitors suffer from poor membrane permeability, we sought to eliminate this characteristic by replacing the basic moiety with non-basic bicyclic acetals and monocyclic ethers. These efforts led to the discovery of the non-zwitterionic aryl sulfonamide 49 as a selective Na(v)1.7 inhibitor with improved membrane permeability. Despite its moderate cellular activity, 49 exhibited robust efficacy in mouse models of neuropathic and inflammatory pain and modulated translational electromyogram measures associated with activation of nociceptive neurons. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2017.08.012

文献信息

• ANTIVIRAL COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：EP3239152A1

  公开（公告）日：2017-11-01

  The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  本公开涉及抗病毒化合物、含有此类化合物的组合物、包括施用此类化合物的治疗方法，以及用于制备此类化合物的工艺和中间体。