lipo-phosphomalate | 1203489-68-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: lipo-phosphomalate
• 英文别名: Myristyl malate phosphonic acid；4-oxo-2-phosphonooxy-4-tetradecoxybutanoic acid
• CAS: 1203489-68-2
• 化学式: C₁₈H₃₅O₈P
• 分子量: 410.445
• InChiKey: HMQUXKOEAPJEIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  27
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-Hydroxy-4-oxo-4-tetradecoxybutanoic acid 在 磷酸 、 二月桂酸二丁基锡 作用下， 以46%的产率得到lipo-phosphomalate
  参考文献：
  名称：

  NEW LIPO-PHOSPHATED OR LIPO-SULPHATED COMPOUND, COMPOSITIONS COMPRISING IT AND TOPICAL USES THEREOF

  摘要：

  公开号：

  EP2525774B1

文献信息

• Lipo-Phosphated or Lipo-Sulphated Compound, Compositions Comprising It and Topical Uses Thereof
  申请人：Fournial Arnaud

  公开号：US20130004439A1

  公开（公告）日：2013-01-03

  The compound according to the invention has the following developed formula IX: wherein: X=PO(OH) 2 ; SO 2 (OH); PO(OH)(Xaa) m or SO 2 (Xaa) m ; A=H; OH; NH 2 or akyl (1-6C); n=1 to 4; Y=—CO—OR 2 ; —CO—NR 3 R 4; —O—CO—R 2; —C═CR 2 ; R 2 =an alkyl, aryl, aralkyl, acyl, sulfonyl, sugar or alkoxy chain of 1 to 24 carbon atoms, linear, branched or cyclic, with or without substitutions, saturated or not, hydroxylated or not, sulfurated or not; R 5 =OH, O-alk (1-6C), (Xaa) m , NH 2 or NH-alkyl(1-6C); Xaa=peptide of m aminoacids Xaa with m from 1 to 10; The compound is preferably phosphated, obtained from malic acid and having the following developed formula: A cosmetic composition comprising the compound of the present invention can improve the general condition of the skin, for example hydration, lightening and mechanical properties.

  本发明所述化合物的结构式为IX，具体如下：其中：X=PO(OH)2；SO2(OH)；PO(OH)(Xaa)m或SO2(Xaa)m；A=H；OH；NH2或烷基(1-6C)；n=1至4；Y=—CO—OR2；—CO—NR3R4；—O—CO—R2；—C═CR2；R2=1至24个碳原子的直链、支链或环状的烷基、芳基、芳基烷基、酰基、磺酰基、糖基或烷氧基，可以有或没有取代基，可以是饱和或不饱和的，可以是羟基化或非羟基化的，可以是硫化或非硫化的；R5=OH、O-烷基(1-6C)、(Xaa)m、NH2或NH-烷基(1-6C)；Xaa=由m个氨基酸Xaa组成的肽，其中m为1至10。该化合物最好是磷酸化的，由苹果酸得到，具有以下结构式：本发明的化妆品组合物可以改善皮肤的总体状况，例如水合、美白和力学性能。
• COSMETIC COMPOSITIONS COMPRISING PLANT EXTRACTS AND USES THEREOF
  申请人：Alumier Europe Limited

  公开号：EP4003274A1

  公开（公告）日：2022-06-01
• [EN] NEW LIPO-PHOSPHATED OR LIPO-SULPHATED COMPOUND, COMPOSITIONS COMPRISING IT AND TOPICAL USES THEREOF<br/>[FR] NOUVEAU COMPOSÉ LIPOPHOSPHATÉ OU LIPOSULFATÉ, COMPOSITIONS COMPRENANT CELUI-CI ET UTILISATIONS TOPIQUES DE CELUI-CI
  申请人：SEDERMA SA

  公开号：WO2011086532A1

  公开（公告）日：2011-07-21

  The compound according to the invention has the following developed fomula IX: Wherein: X = PO(OH)2, SO2(OH); PO(OH)(Xaa)m or SO2(Xaa)m; A = H; OH; NH2 or akyl (1-6C); n = 1 to 4; Y= -CO- OR2; -CO-NR3R4, -0-CO-R2, -C=CR2; R2 = an alkyl, aryl, aralkyl, acyl, sulfonyl, sugar or alkoxy chain of 1 to 24 carbon atoms, linear, branched or cyclic, with or without substitutions, saturated or not, hydroxylated or not, sulfurated or not; R5 = OH, O-alk (1-6C), (Xaa)m, NH2 or NH-alkyl(l-6C); Xaa = peptide of m aminoacids Xaa with m from 1 to 10; The compound is preferably phosphated, obtained from malic acid and having the following developed formula: A cosmetic composition comprising the compound of the present invention can improve the general condition of the skin, for example hydration, lightening and mechanical properties.
• [EN] COSMETIC COMPOSITIONS COMPRISING PLANT EXTRACTS AND USES THEREOF<br/>[FR] COMPOSITIONS COSMÉTIQUES COMPRENANT DES EXTRAITS VÉGÉTAUX ET LEURS UTILISATIONS
  申请人：ALUMIER EUROPE LTD

  公开号：WO2021013973A1

  公开（公告）日：2021-01-28

  The invention features cosmetic compositions comprising Swertia chirata extract and hydrolyzed Ceratonia siliqua seed extract formulated for topical administration and their related uses, e.g., for reducing skin aging or wrinkles.
• NEW LIPO-PHOSPHATED OR LIPO-SULPHATED COMPOUND, COMPOSITIONS COMPRISING IT AND TOPICAL USES THEREOF
  申请人：Sederma

  公开号：EP2525774B1

  公开（公告）日：2016-03-30