N-[(1S)-1-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]ethyl]cyclopropanecarboxamide | 1313745-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-[(1S)-1-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]ethyl]cyclopropanecarboxamide
• 英文别名: N-[(1S)-1-(4-{3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl)phenyl)-ethyl]cyclopropanecarboxamide
• CAS: 1313745-71-9
• 化学式: C₂₅H₂₃F₉N₂O
• 分子量: 538.456
• InChiKey: GPXZGXRWKYIDSH-XLEXHMCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  N-[(1S)-1-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]ethyl]cyclopropanecarboxamide 在 亚碘酰苯 、 铁粉 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 生成 N-[(1S)-1-(4-{3-[3,5-bis(trifluoroniethyl)phenyl]-2-hydroxy-3-(trifluoromethyl)pyrrolidin-1-yl}phenyl)ethyl]cyclopropanecarboxamide
  参考文献：
  名称：

  [EN] PESTICIDAL ARYLPYRROLIDINES
  [FR] ARYLPYRROLIDINES PESTICIDES

  摘要：

  公式（I）中的芳基吡咯烷：其中每个取代基如规范中定义，并将其用作杀虫剂和动物寄生虫控制剂。

  公开号：

  WO2012035011A1
• 作为产物：
  描述：

  3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidine 、 (S)-cyclopropanecarboxylic acid [1-(4-bromo-phenyl)-ethyl]-amide 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 sodium t-butanolate 作用下， 以 甲苯 为溶剂， 反应 0.17h， 生成 N-[(1S)-1-[4-[3-[3,5-bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl]phenyl]ethyl]cyclopropanecarboxamide
  参考文献：
  名称：

  [EN] PESTICIDAL ARYLPYRROLIDINES
  [FR] ARYLPYRROLIDINES PESTICIDES

  摘要：

  本发明涉及一种新型杀虫剂芳基吡咯烷化合物（芳基吡咯烷），其通式为（I），其中A，X1，X2，X3，X4，R1，R2，R3，R4和G如申请中所定义，并且它们的用途作为杀虫剂，特别是用于防治农业和/或兽医领域中出现的动物害虫，以及用于制备这种化合物的制备方法。

  公开号：

  WO2011080211A1

文献信息

• [EN] METHODS OF PEST CONTROL IN SOYBEAN<br/>[FR] PROCÉDÉ DE LUTTE CONTRE DES ORGANISMES NUISIBLES S'ATTAQUANT AU SOJA
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014019609A1

  公开（公告）日：2014-02-06

  The present invention provides methods comprising applying to a crop of soybean plants, the locus thereof, or propagation material thereof, a compound a compound of formula (I) wherein -B1-B2-B3- is -C=N-O-, -C=N-CH2-, -N-CH2-CH2-, or -C=C-O-; R1 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl; R2 is group (X) wherein X2 is C-X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least one of X1, X3 and X6 is not hydrogen; A is selected from group (A1) to (A4) and Y1, Y2, Y3, R5 and R8 are as defined in claim 1. The methods are preferably for the control of stinkbugs, in particular Euschistus.

  本发明提供了一种方法，包括将化合物应用于大豆植株、其基因座位或繁殖材料，所述化合物的化学式为(I)，其中-B1-B2-B3-为-C=N-O-，-C=N-CH2-，-N- - -或-C=C-O-；R1为三氟甲基、二氟甲基或氯二氟甲基；R2为(X)基团，其中X2为C-X6或氮；X1、X3和X6独立地为氢、卤素或三卤甲基，其中至少一个X1、X3或X6不是氢；A选自(A1)至(A4)组和Y1、Y2、Y3、R5和R8如权利要求1所定义。该方法优选用于控制臭虫，特别是Euschistus。
• [EN] METHODS OF CONTROLLING INSECTS<br/>[FR] PROCÉDÉS DE CONTRÔLE DES INSECTES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014029708A1

  公开（公告）日：2014-02-27

  The present invention provides provides a method for controlling and/or preventing insects from the genus of Plutella in useful plants, comprising applying to a crop of useful plants, the locus thereof, or propagation material thereof, a compound of formula (I), wherein -B1-Β2-Β3- is -C=N-O-, -C=N-CH2-, or -N-CH2-CH2-; R1 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl; R2 is group X X2 is C-X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least one of X1, X3 and X6 is not hydrogen; A is selected from A1 to A5 Y1 is C-R6, CH or nitrogen; Y2 and Y3 are independently CH or nitrogen; wherein no more than two of Y1, Y2 and Y3 are nitrogen and wherein Y2 and Y3 are not both nitrogen; R5 is hydrogen, halogen, cyano, nitro, NH2, C1-C4alkyl, C1C4aloalkyl, C3-C5cycloalkyl, C3- C5halocycloalkyl, C1-C2alkoxy, or C1-C2haloalkoxy, preferably provided that when A is A3 or A4 R5 is not hydrogen; R6 when present together with R5 forms a -CH=CH-CH=CH- bridge; R7 is C1C4alkyl; R8 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy(C1-C4)alkyl, C1-C4alkylthio(C1-C4)alkyl, C1- C4alkylsulfinyl(C1-C4)alkyl, C1-C4alkylsulfonyl(C1-C4)alkyl, C3-C6cycloalkyl, C3-C6cycloalkyl(C1-C4)alkyl-, or tetrahydrofuranyl; R9 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkyl-O-CH2-, C1-C4haloalkyl-O-CH2-,C3-C6cycloalkyl, C3-C6cycloalkyl-CH2-, C1-C4alkyl-S-CH2-, C1-C4alkyl-S(O)-CH2-, or C1-C4alkyl-S(O2)-CH2; each Z is independently halogen, C1-C12alkyl or C1-C12alkyl substituted by one to five R12, nitro, C1-C12alkoxy or C1-C12alkoxy substituted by one to five R12 cyano, C1-C12alkylsulfinyl, C1-C12alkylsulfonyl, C1-C12haloalkylsulfinyl, C1-C12haloalkylsulfonyl, hydroxyl or thiol; each R12 is halogen, cyano, nitro, hydroxy, C1-C8alkoxy-, C1-C8haloalkoxy-, mercapto, C1-C8alkylthio-, or C1-C8haloalkylthio; and k is 0, 1,2 or 3.

  本发明提供了一种用于控制和/或预防有用植物中十字花科昆虫属的昆虫的方法，包括将式(I)的化合物施用于有用植物的作物、其位点或繁殖材料，其中-B1-Β2-Β3-为-C=N-O-，-C=N-CH2-或-N- - -；R1为三氟甲基、二氟甲基或氯二氟甲基；R2为X的基团，X2为C-X6或氮；X1、X3和X6独立地为氢、卤素或三卤甲基，其中X1、X3和X6中至少有一个不是氢；A从A1到A5中选择，Y1为C-R6、CH或氮；Y2和Y3独立地为CH或氮；其中Y1、Y2和Y3中不超过两个是氮，且Y2和Y3不同时为氮；R5为氢、卤素、氰基、硝基、NH2、C1-C4烷基、C1-C4烷氧基、C3-C5环烷基、C3-C5卤代环烷基、C1-C2烷氧基或C1-C2卤代烷氧基，优选当A为A3或A4时R5不是氢；R6与R5一起形成一个-CH=CH-CH=CH-桥；R7为C1C4烷基；R8为C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧(C1-C4)烷基、C1-C4烷硫基(C1-C4)烷基、C1-C4烷基亚砜基(C1-C4)烷基、C1-C4烷基砜基(C1-C4)烷基、C3-C6环烷基、C3-C6环烷基(C1-C4)烷基或四氢呋喃基；R9为C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧- -、C1-C4卤代烷氧- -、C3-C6环烷基、C3-C6环烷基- -、C1-C4烷硫- -、C1-C4烷硫氧- -或C1-C4烷硫氧2- ；每个Z独立地为卤素、C1-C12烷基或被1至5个R12取代的C1-C12烷基，硝基，C1-C12烷氧基或被1至5个R12取代的C1-C12烷氧基，氰基，C1-C12烷基亚砜基，C1-C12烷基砜基，C1-C12卤代烷基亚砜基，C1-C12卤代烷基砜基，羟基或硫醇；每个R12为卤素，氰基，硝基，羟基，C1-C8烷氧基，C1-C8卤代烷氧基，巯基，C1-C8烷硫基或C1-C8卤代烷硫基；k为0、1、2或3。
• Pesticidal Arylpyrrolidines
  申请人：Mihara Jun

  公开号：US20120322833A1

  公开（公告）日：2012-12-20

  The present invention relates to novel pesticidal arylpyrrolidine compounds (arylpyrrolidines) having the general formula (I) wherein A, X 1 , X 2 , X 3 , X 4 , R 1 , R 2 , R 3 , R 4 , and G are as defined in the application and their use as pesticide, in particular for combating animal pests which occur in the agricultural and/or the veterinary field, as well as to a preparation methods for preparing such compounds.

  本发明涉及一种新型杀虫的芳基吡咯烷化合物（芳基吡咯烷），其通式为（I），其中A、X1、X2、X3、X4、R1、R2、R3、R4和G如本申请中所定义，并且它们的用途是作为杀虫剂，特别是用于防治农业和/或兽医领域中出现的动物害虫，还包括制备这种化合物的制备方法。
• PESTICIDAL ARYLPYRROLIDINES
  申请人：Mihara Jun

  公开号：US20140046069A1

  公开（公告）日：2014-02-13

  Arylpyrrolidines of Formula (I): wherein each substituent is as defined in the specification, and use thereof as pesticides and animal paracite-controlling agents.

  式（I）的芳基吡咯烷化合物：其中每个取代基如规范中所定义，并将其用作杀虫剂和动物寄生虫控制剂。
• Pesticidal arylpyrrolidines
  申请人：Mihara Jun

  公开号：US08536201B2

  公开（公告）日：2013-09-17

  The present invention relates to novel pesticidal arylpyrrolidine compounds (arylpyrrolidines) having the general formula (I) wherein A, X1, X2, X3, X4, R1, R2, R3, R4, and G are as defined in the application and their use as pesticide, in particular for combating animal pests which occur in the agricultural and/or the veterinary field, as well as to a preparation methods for preparing such compounds.

  本发明涉及一种新型的杀虫芳基吡咯烷化合物（芳基吡咯烷），其通式为（I），其中A、X1、X2、X3、X4、R1、R2、R3、R4和G的定义如本申请所述，并且其用作杀虫剂，特别是用于防治农业和/或兽医领域中出现的动物害虫，以及制备这种化合物的制备方法。