(S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester | 1397342-95-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester
• 英文别名: (S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4lambda6-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester；(S)-3-(2-Chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4lambda*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester；methyl (3S)-3-(2-chlorophenyl)-3-[(5,5,6,6-tetramethyl-4,4-dioxo-1,4,3-oxathiazinan-2-ylidene)amino]propanoate
• CAS: 1397342-95-8
• 化学式: C₁₇H₂₃ClN₂O₅S
• 分子量: 402.899
• InChiKey: KSZWMWHRWZJEEQ-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  102
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester 、 甲基溴化镁 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.05h， 以35 mg的产率得到(S)-4-(2-chlorophenyl)-2-methyl-4-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ6-[1,4,3]oxathiazin-2-ylamino)butan-2-ol
  参考文献：
  名称：

  TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF

  摘要：

  该发明涉及式(I)的化合物以及其生理上可接受的盐。所述化合物适用于治疗高血糖等情况。

  公开号：

  US20140024584A1
• 作为产物：
  描述：

  2,3-二甲基-2-丁烯 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.08h， 生成 (S)-3-(2-chlorophenyl)-3-(5,5,6,6-tetramethyl-4,4-dioxo-5,6-dihydro-4H-4λ*6*-1,4,3-oxathiazin-2-ylamino)propionic acid methyl ester
  参考文献：
  名称：

  TETRASUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF

  摘要：

  该发明涉及式(I)的化合物以及其生理上可接受的盐。所述化合物适用于治疗高血糖等情况。

  公开号：

  US20140024584A1

文献信息

• DI- AND TRI-SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130345125A1

  公开（公告）日：2013-12-26

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及式(I)的化合物及其生理兼容盐。所述化合物适用于治疗高血糖，例如。
• DI AND TRI - SUBSTITUTED OXATHIAZINE DERIVATIVES, METHOD FOR THE PRODUCTION, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND USE THEREOF
  申请人：Boehme Thomas

  公开号：US20130338150A1

  公开（公告）日：2013-12-19

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  该发明涉及公式（I）的化合物及其生理兼容盐。这些化合物适用于治疗高血糖，例如。
• Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
  申请人：Boehme Thomas

  公开号：US08871758B2

  公开（公告）日：2014-10-28

  The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.

  本发明涉及式(I)的化合物及其生理上可接受的盐。所述化合物适用于例如治疗高血糖等方面。
• Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08710050B2

  公开（公告）日：2014-04-29

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及式(I)化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。
• Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
  申请人：Boehme Thomas

  公开号：US08828994B2

  公开（公告）日：2014-09-09

  The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.

  本发明涉及公式(I)的化合物及其生理相容盐。该化合物适用于治疗高血糖等疾病。