4-ethoxy-benzaldehyde-selenosemicarbazone | 115231-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-ethoxy-benzaldehyde-selenosemicarbazone
• 英文别名: 4-Aethoxy-benzaldehyd-selenosemicarbazon
• CAS: 115231-20-4
• 化学式: C₁₀H₁₃N₃OSe
• 分子量: 270.193
• InChiKey: RBWJIDBYGWVEKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.22
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  59.64
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  4-乙氧基苯甲醛 、 acetone selenosemicarbazone 在 溶剂黄146 作用下， 以 水 为溶剂， 生成 4-ethoxy-benzaldehyde-selenosemicarbazone
  参考文献：
  名称：

  BE544031

  摘要：

  公开号：

文献信息

• The Anticalcific Effect of Glutaraldehyde Detoxification on Bioprosthetic Aortic Wall Tissue in the Sheep Model
  作者：Peter Zilla、Christoph Weissenstein、Mona Bracher、Paul Human

  DOI：10.1111/j.1540-8191.2001.tb00551.x

  日期：2001.11

  Background: Increasing concentrations of glutaraldehyde (GA) lead to a decreased rather than increased calcification of bioprosthetic aortic wall tissue. This study determined to what extent the benefit of better cross-linking is masked by the intrinsic propensity of GA towards calcification. Materials and Methods: Porcine aortic roots were immediately fixed at the abattoir at three different concentrations of GA (0.2%, 1.0%, and 3.0% for 1 week at 4 C). Subsequently, roots underwent a GA extraction process using high volumes of Urazole solution (acetic acid buffer, pH 4.5, 37degreesC, 1 week) followed by NaBH4 reduction (2 days, 37 C). Roots were implanted in the distal aortic arch of young sheep for 6 weeks and 6 months. Calcium analysis was quantitatively done by atomic absorption spectrophotometry and qualitatively assessed by light microscopy on Von Kossa stains. Results: There was a distinct anticalcification effect of GA detoxification after 6 weeks (56.8% to 97.9%; 95% confidence interval [CI]), which stabilized on a more moderate level after 6 months of implantation (19.1% to 31.6%; 95% CI). The most pronounced effect of GA extraction was seen in 0.2% fixed tissue, where aortic wall calcification was mitigated by 97% and 32% after 6 weeks and 6 months, respectively. Mitigation of aortic wall calcification was 71% (6 weeks) and 21% (6 months) in the 3.0% GA group. The combined effect of higher cross-link density and detoxification achieved an 82% (6 weeks) and 48% (6 months) reduction of calcium levels in the 3.0% GA group. In long-term implants (6 months), detoxification alone on top of standard 0.2% GA fixation was as effective (from 174.1 +/- 11.9 mug/mg without detoxification to 119.3 +/- 19.3 mug/mg with detoxification) as 3.0% fixation (114.8 +/- 10.0 mug/mg without detoxification to 91.3 +/- 11.5 mug/mg with detoxification). Conclusion: We were able to determine in the circulatory sheep model to what degree the intrinsic procalcific effect of GA counteracts the protective effect of higher cross-link density. Our study also established that the effect of detoxification is particularly pronounced in commercial low-grade fixation.