7-Mercapto-indol | 89942-92-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7-Mercapto-indol
• 英文别名: indole-7-thiole；1H-indole-7-thiol
• CAS: 89942-92-7
• 化学式: C₈H₇NS
• mdl: MFCD19221973
• 分子量: 149.216
• InChiKey: BEPKJAXROVBBID-UHFFFAOYSA-N

物化性质

• 沸点：
  326.6±15.0 °C(Predicted)
• 密度：
  1.303±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  16.8
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• Indole derivatives comprising an acetylene group
  申请人：Ackermann Jean

  公开号：US20060035956A1

  公开（公告）日：2006-02-16

  This invention is directed to compounds of the formula (I): wherein one of R 6 , R 7 , R 8 and R 9 is and X, R 1 to R 12 , m, n and o are as defined in the description, and pharmaceutically acceptable salts and/or esters thereof. The invention is also directed to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.

  这项发明涉及式(I)的化合物：其中R6、R7、R8和R9中的一个是X，R1到R12，m，n和o如描述中所定义，并且其药学上可接受的盐和/或酯。该发明还涉及含有这种化合物的药物组合物，以及用于治疗和/或预防由PPARδ和/或PPARα激动剂调节的疾病的方法。
• Modulators of sphingosine phosphate receptors
  申请人：The Scripps Research Institute

  公开号：US10544136B2

  公开（公告）日：2020-01-28

  Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

  本研究提供了能激活亚型 1 的鞘氨醇-1-磷酸受体的化合物。与鞘氨醇-1-磷酸受体亚型 3 相比，某些化合物可选择性地激活受体亚型 1。本发明提供了本发明化合物的用途和方法，用于治疗S1P1的活化、激动、抑制或拮抗在医学上适用的不良病症。
• INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1781608A1

  公开（公告）日：2007-05-09
• NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
  申请人：The Scripps Research Institute

  公开号：US20190084947A1

  公开（公告）日：2019-03-21

  Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine- 1 -phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.
• OPTICAL PRODUCT AND OPTICAL FILTER INCLUDING SAME
  申请人：LMS Co., Ltd.

  公开号：US20200241185A1

  公开（公告）日：2020-07-30

  The present invention relates to an optical article, and an optical filter and an imaging device including the same. The optical article comprises: a near-infrared absorption glass substrate including a divalent copper ion as a chromatic ingredient; and a pigment dispersion layer formed on one surface or both surfaces of the near-infrared absorption glass substrate and having a near-infrared absorption pigment and an ultraviolet absorption pigment dispersed across the resin matrix thereof. Provided with a first and a second transmission cut-off region, the optical article has the advantage of allowing the fabrication of an excellent near-infrared cut-off filter that can effectively block light in near-infrared and ultraviolet bands and does not permit a difference in color sense with the change of incident angles.