(5-chloro-1H-indol-2-yl)-(3-methylpiperazin-1-yl)methanone | 459169-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (5-chloro-1H-indol-2-yl)-(3-methylpiperazin-1-yl)methanone
• 英文别名: (5-chloro-1H-indol-2-yl)-[(3S)-3-methylpiperazin-1-yl]methanone
• CAS: 459169-45-0
• 化学式: C₁₄H₁₆ClN₃O
• 分子量: 277.754
• InChiKey: ZFOCPCZMOWXMNL-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  48.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• HETEROCYCLIC COMPOUNDS
  申请人：Janssen Pharmaceuticals, Inc.

  公开号：EP1373204B1

  公开（公告）日：2016-10-26
• USE OF HISTAMINE H4 RECEPTOR MODULATORS FOR THE TREATMENT OF ALLERGY AND ASTHMA
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP1545596A2

  公开（公告）日：2005-06-29
• EP1545596A4
  申请人：——

  公开号：EP1545596A4

  公开（公告）日：2005-12-28
• [EN] USE OF HISTAMINE H4 RECEPTOR MODULATORS FOR THE TREATMENT OF ALLERGY AND ASTHMA<br/>[FR] UTILISATION DE MODULATEURS DU RÉCEPTEUR H4 DE L'HISTAMINE POUR LE TRAITEMENT DES ALLERGIES ET DE L'ASTHME
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2004021999A2

  公开（公告）日：2004-03-18

  Methods are disclosed for identifying histamine receptor modulators that affect mast cell or basophil chemotaxis, and the use of such histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of asthma and/or allergic responses, or diseases and/or conditions that are modulated, affected or caused by asthma or allergic responses. Also disclosed is the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of mast cell or basophil chemotactic responses, such as migration to a particular site, or diseases and/or conditions that are modulated, affected or caused by mast cell or basophil chemotaxis.