methyl 4'-hydroxy-6,6-dimethyl-1,1'-bis(4-methoxyphenyl)-2,4,5'-trioxo-1,1',2,4,5,5',6,7-octahydrospiro[indole-3,2'-pyrrole]-3'-carboxylate | 1352655-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: methyl 4'-hydroxy-6,6-dimethyl-1,1'-bis(4-methoxyphenyl)-2,4,5'-trioxo-1,1',2,4,5,5',6,7-octahydrospiro[indole-3,2'-pyrrole]-3'-carboxylate
• 英文别名: methyl 4'-hydroxy-1,1'-bis(4-methoxyphenyl)-6,6-dimethyl-2,4,5'-trioxospiro[5,7-dihydroindole-3,2'-pyrrole]-3'-carboxylate
• CAS: 1352655-53-8
• 化学式: C₂₉H₂₈N₂O₈
• 分子量: 532.55
• InChiKey: NKXMWLHZICBNIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  39
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  3-[(4-甲氧苯基)氨基]-5,5-二甲基-1-环己-2-烯酮 、 4,5-dimethoxycarbonyl-1-(4'-methoxyphenyl)-1H-pyrrole-2,3-dione 以 甲苯 为溶剂， 以71%的产率得到methyl 4'-hydroxy-6,6-dimethyl-1,1'-bis(4-methoxyphenyl)-2,4,5'-trioxo-1,1',2,4,5,5',6,7-octahydrospiro[indole-3,2'-pyrrole]-3'-carboxylate
  参考文献：
  名称：

  Five-membred 2,3-dioxoheterocycles: LXXXI. Reactions of 4,5-bis(methoxycarbonyl)-1H-pyrrole-2,3-diones with N-substituted 3-amino-5,5-dimethyl-2-cyclohex-2-en-1-ones. crystal and molecular structure of methyl 4′-hydroxy-6,6-dimethyl-1,1′-bis(4-methylphenyl)-2,4,5′-trioxo-1,1′,2,4,5,5′,6,7-octahydrospiro[indole-3,2′-pyrrole]-3′-carboxylate

  摘要：

  1-Aryl-4,5-bis(methoxycarbonyl)-1H-pyrrole-2,3-diones react with N-substituted 3-amino-5,5-dimethylcyclohex-2-en-1-ones affording methyl 1,1'-diaryl-4'-hydroxy-6,6-dimethyl-2,4,5'-trioxo-1,1',2,4,5,5',6,7-octahydrospiro[indole-3,2'-pyrrole]-3'-carboxylates whose structure was proved by XRD analysis.

  DOI：

  10.1134/s107042801111011x