(9S)-9-ethyl-9-hydroxy-1-pentyl-2-propyl-1H,12H-pyrano[3",4":6',7']indolizino-[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione | 538374-81-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 喜树碱
• 英文名称: (9S)-9-ethyl-9-hydroxy-1-pentyl-2-propyl-1H,12H-pyrano[3",4":6',7']indolizino-[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione
• 英文别名: (10S)-10-ethyl-10-hydroxy-23-pentyl-22-propyl-8-oxa-4,15,21,23-tetrazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16(24),17,19,21-octaene-5,9-dione
• CAS: 538374-81-1
• 化学式: C₂₉H₃₂N₄O₄
• 分子量: 500.597
• InChiKey: UTGPCZXENDNUBY-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  95.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Novel hexacyclic compounds
  申请人：——

  公开号：US20030144304A1

  公开（公告）日：2003-07-31

  The present invention relates to hexacyclic compound of the formula [1], 1 wherein Z, R 3 and R 4 are as identified therein, and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of cell proliferative disorders.

  本发明涉及公式［1］中的六环化合物，其中Z、R3和R4如所述，以及其药用可接受的盐。这些化合物可用于治疗细胞增殖性疾病。
• Novel process for the preparation of hexacyclic compounds
  申请人：Fukuda Hiroshi

  公开号：US20060178376A1

  公开（公告）日：2006-08-10

  This invention relates to novel processes for the preparation of compounds of the formula [1], wherein R1, R2, R3 and R4 are as defined in the claims and description as well as pharmaceutically acceptable salts thereof. The compounds of the formula [1] are hexacyclic compounds having potent anti-tumor activity.

  本发明涉及一种制备公式[1]化合物的新型工艺，其中R1，R2，R3和R4如权利要求和说明书中所定义，并且它们的药学上可接受的盐。公式[1]化合物是具有强大的抗肿瘤活性的六环化合物。
• Novel Process for the Preparation of Hexacyclic Compounds
  申请人：FUKUDA HIROSHI

  公开号：US20090312554A1

  公开（公告）日：2009-12-17

  This invention relates to novel processes for the preparation of compounds of the formula [1], wherein R 1 , R 2 , R 3 and R 4 are as defined in the claims and description as well as pharmaceutically acceptable salts thereof. The compounds of the formula [ 1 ] are hexacyclic compounds having potent anti-tumor activity.

  本发明涉及一种新的制备式[1]化合物的方法，其中R1、R2、R3和R4如权利要求和说明书中所定义，以及其药学上可接受的盐。式[1]化合物是具有强效抗肿瘤活性的六环化合物。
• HEXACYCLIC COMPOUNDS
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1480984B9

  公开（公告）日：2009-03-11
• CONDENSED CAMPTOTHECINS AS ANTITUMOR AGENTS
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1480984B1

  公开（公告）日：2008-06-11