(6-chloro-3-methylquinolin-2-yl)ferrocene | 1415117-38-2

• 英文名称: (6-chloro-3-methylquinolin-2-yl)ferrocene
• CAS: 1415117-38-2
• 化学式: C₂₀H₁₆ClFeN
• 分子量: 361.654
• InChiKey: CKIBQWCSZSWJJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  propionylferrocene 、 2-氨基-5-氯苯甲醛 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 反应 36.0h， 以23%的产率得到(6-chloro-3-methylquinolin-2-yl)ferrocene
  参考文献：
  名称：

  Efficient Synthesis of Ferrocenylquinolines via the Friedländer Reaction

  摘要：

  Acylferrocenes 2a-c reacted with ortho-aminoarylaldehydes 1a-e via the Friedlander condensation reaction to afford the corresponding ferrocenylquinolines 3a-o in moderate yields in the presence of sodium ethoxide (30 mmol%) under mild reaction conditions. Under the same reaction conditions, 1,1'-diacetylferrocene 2d and 1,1'-dipropionylferrocene 2e reacted with ortho-aminoaldehydes 1a-e to afford the corresponding 1,1'-bis(substituted quinolin-2-yl) ferrocene derivatives 3p-t. The structures of compounds 3a-t were determined and characterized by infrared, H-1 NMR, mass spectrometry, and elemental analysis. The crystal structures of 3e and 3q were determined by x-ray crystallography.

  DOI：

  10.1080/00397911.2010.519090