methyl 2-[(1R,2R,6R,7S,10R,11R)-4,4-dimethyl-3,5,8,12,13-pentaoxatetracyclo[8.2.1.02,6.07,11]tridecan-1-yl]acetate | 214078-45-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧吡喃
• 英文名称: methyl 2-[(1R,2R,6R,7S,10R,11R)-4,4-dimethyl-3,5,8,12,13-pentaoxatetracyclo[8.2.1.02,6.07,11]tridecan-1-yl]acetate
• CAS: 214078-45-2
• 化学式: C₁₃H₁₈O₇
• 分子量: 286.282
• InChiKey: WDLQEIHEAXECGB-UCXBFWQKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  72.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  methyl 2-[(1R,2R,6R,7S,10R,11R)-4,4-dimethyl-3,5,8,12,13-pentaoxatetracyclo[8.2.1.02,6.07,11]tridecan-1-yl]acetate 在 吡啶 、 lithium aluminium tetrahydride 作用下， 生成
  参考文献：
  名称：

  Wittig olefination of partially protected sugar lactones: A direct entry to dioxabicyclic and trioxatricyclic systems

  摘要：

  Partially protected sugar lactones reacts with stabilized phosphoranes at high temperature yielding activated olefins which undergo subsequent 1,4-addition to give bicyclic adducts, simultaneous furan formation being also observed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00676-5
• 作为产物：
  描述：

  甲氧羰基亚甲基三苯基正膦 、 (3aR,6aR)-2,2-Dimethyl-6-((1R,2R)-1,2,3-trihydroxy-propyl)-dihydro-furo[3,4-d][1,3]dioxol-4-one 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 以60%的产率得到methyl 2-[(1R,2R,6R,7S,10R,11R)-4,4-dimethyl-3,5,8,12,13-pentaoxatetracyclo[8.2.1.02,6.07,11]tridecan-1-yl]acetate
  参考文献：
  名称：

  Wittig olefination of partially protected sugar lactones: A direct entry to dioxabicyclic and trioxatricyclic systems

  摘要：

  Partially protected sugar lactones reacts with stabilized phosphoranes at high temperature yielding activated olefins which undergo subsequent 1,4-addition to give bicyclic adducts, simultaneous furan formation being also observed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00676-5