N2-(4-diethylamino-1-methyl-butyl)-N4-(1H-indol-6-yl)-pyrimidine-2,4-diamine | 1249398-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N2-(4-diethylamino-1-methyl-butyl)-N4-(1H-indol-6-yl)-pyrimidine-2,4-diamine
• 英文别名: 2-N-[5-(diethylamino)pentan-2-yl]-4-N-(1H-indol-6-yl)pyrimidine-2,4-diamine
• CAS: 1249398-13-7
• 化学式: C₂₁H₃₀N₆
• 分子量: 366.509
• InChiKey: ARUNEWNMYLNIJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  68.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• New RAC1 inhibitors as potential pharmacological agents for heart failure treatment
  申请人：UNIVERSITA' DEGLI STUDI DI MILANO

  公开号：EP2241555A1

  公开（公告）日：2010-10-20

  The present invention finds application in the field of medicine and, in particular, to new compounds of formula (I) and pharmaceutical preparations containing them useful for the treatment and/or prevention of heart failure.

  本发明适用于医学领域，特别是针对新化合物(I)的应用，以及包含这些化合物的药物制剂，用于治疗和/或预防心力衰竭。
• [EN] NEW RAC1 INHIBITORS AS POTENTIAL PHARMACOLOGICAL AGENTS FOR HEART FAILURE TREATMENT<br/>[FR] NOUVEAUX INHIBITEURS DE RAC1 EN TANT QU'AGENTS PHARMACOLOGIQUES POTENTIELS POUR UN TRAITEMENT D'UNE INSUFFISANCE CARDIAQUE
  申请人：UNIV DEGLI STUDI MILANO

  公开号：WO2010119050A1

  公开（公告）日：2010-10-21

  The present invention finds application in the field of medicine and, in particular, to new compounds particularly active in inhibiting Rac1 member of the Rho family. Pharmaceutical preparations containing them useful for the treatment and/or prevention of heart failure are disclosed as well.