| 1598436-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• CAS: 1598436-34-0
• 化学式: C₂₅H₂₃ClN₂O
• 分子量: 402.923
• InChiKey: MZGBPKUKLUFYOG-UHFFFAOYSA-N

物化性质

• 沸点：
  557.4±60.0 °C(predicted)
• 密度：
  1.16±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  、 丁炔二酸二甲酯 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以60%的产率得到tetramethyl 1-benzyl-1′-(4-tert-butylphenyl)-5-chloro-2-oxo-1′H-spiro[indoline-3,2′-pyridine]-3′,4′,5′,6′-tetracarboxylate
  参考文献：
  名称：

  Selective Synthesis of Functionalized Spiro[indoline-3,2′-pyridines] and Spiro[indoline-3,4′-pyridines] by Lewis Acid Catalyzed Reactions of Acetylenedicarboxylate, Arylamines, and Isatins

  摘要：

  The functionalized spiro[indoline-3,2'-pyridine]-3',4',5',6'-tetracarboxylates were efficiently synthesized by BF3 center dot OEt2-catalyzed reactions of isatin-3-imines with acetylenedicarboxylates in methylene dichloride. Under similar conditions, the BF3 center dot OEt2-catalyzed three-component reactions of acetylenedicarboxylates, arylamines, and isatins afforded functionalized spiro[indoline-3,4'-pyridine]-2',3',5',6'-tetracarboxylates in moderate yields.

  DOI：

  10.1021/jo500144z