柠檬酸甜菜碱 | 17671-50-0

• 物质功能分类: 表面活性剂 - 两性离子表面活性剂 - 甜菜碱型
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 柠檬酸甜菜碱
• 英文名称: betaine-citric acid
• 英文别名: Betain-dihydrogencitrat；2-(Carboxymethyl)-2,4-dihydroxy-4-oxobutanoate;carboxymethyl(trimethyl)azanium
• CAS: 17671-50-0
• 化学式: C₅H₁₁NO₂*C₆H₈O₇
• 分子量: 309.273
• InChiKey: YKXUOESQDCXGIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.81
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  172
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 海关编码：
  2923900090

制备方法与用途

外观

白色至灰白色晶体，无味或微弱的特征气味。

功效与作用

甜菜碱是一种重要的人体营养素，广泛分布于动物，植物和微生物中。它被迅速吸收并用作渗透物和甲基的来源，从而有助于维持肝脏，心脏和肾脏的健康。越来越多的证据表明，甜菜碱是预防慢性病的重要营养素。
甜菜碱柠檬酸盐是柠檬酸盐，是化学技术的新产品。它专门用于提供甜菜碱以改善肝功能和作为肝脏保护剂。一些研究表明，柠檬酸甜菜碱可能有效治疗心血管疾病。它还可用作食品再分散剂，防腐剂和抗氧化剂。甜菜碱柠檬酸盐可以被身体完全吸收，没有或几乎没有副作用，但需要进一步的研究来证明它的安全性。

文献信息

• A method of reducing the rate of degradation of a biological material
  申请人：Bio-Energy Ingredients Limited

  公开号：EP2633762A1

  公开（公告）日：2013-09-04

  A method of producing an animal feed product from a wet biological material, having a physical form selected from solutions, suspensions, emulsions, gums, mousses, sludges, slurries, and particulate materials, includes the step of combining the biological material with a base comprising a metal oxide in an amount which is sufficient to heat the biological material to a temperature of above 50°C by reaction of water in the biological material with the metal oxide to produce the animal feed product. The product has a physical form which is easier to handle than that of the wet biological material and is selected from particulate materials and, granular materials. The base is preferably calcium oxide.

  一种用湿生物材料生产动物饲料产品的方法，该湿生物材料的物理形态选自溶液、悬浮液、乳剂、胶状物、糊状物、淤泥、泥浆和颗粒材料，该方法包括以下步骤：将生物材料与含有金属氧化物的基质结合，基质的用量足以通过生物材料中的水与金属氧化物的反应将生物材料加热到 50°C 以上的温度，从而生产出动物饲料产品。该产品的物理形态比湿生物材料更容易处理，可从颗粒材料和粒状材料中选择。碱最好是氧化钙。
• SPHERICAL INORGANIC PARTICLES HAVING SURFACE BUMPS FORMED THEREON, AND METHOD OF MANUFACTURING SAME
  申请人：Bead Origin Inc.

  公开号：EP3957699A2

  公开（公告）日：2022-02-23

  The inorganic particle according to the present invention is composed of aggregation of crystalline and amorphous small particles and has a spherical and smooth surface. The spherical appearance, low crystallinity and narrow particle size distribution of inorganic particle are more advantageous in reducing scratch defects in the CMP process. In addition, since the small particles on the surface of the inorganic particle provide more active sites, the inorganic particle has an excellent removal rate, so it is advantageous as a next-generation CMP abrasive.

  本发明的无机颗粒由结晶和无定形小颗粒聚集而成，具有球形和光滑的表面。无机颗粒的球形外观、低结晶度和窄粒度分布更有利于减少 CMP 工艺中的划痕缺陷。此外，由于无机颗粒表面的小颗粒提供了更多的活性位点，无机颗粒具有极佳的去除率，因此作为下一代 CMP 研磨剂具有优势。
• Systems to promote healing at a site of a medical device
  申请人：TEMPO THERAPEUTICS, INC.

  公开号：US10576185B2

  公开（公告）日：2020-03-03

  Disclosed herein are systems for promoting healing of a wound or surgical incision at a medical device site (e.g., implanted medical device) in a subject, by administering a microporous gel to the medical implant site. Also disclosed are systems for the treatment and prevention of infection at a medical implant site in a subject, by administering a microporous gel to the medical implant site. The microporous gel may be fluidic during application and annealed or crosslinked after application. The microporous gels may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.

  本文公开了通过向医疗植入物部位施用微孔凝胶促进受试者医疗器械部位（如植入医疗器械）的伤口或手术切口愈合的系统。还公开了通过向医疗植入部位施用微孔凝胶来治疗和预防受试者医疗植入部位感染的系统。微孔凝胶在施用时可以是流动的，施用后可以退火或交联。微孔凝胶中可能含有各种治疗剂，包括抗生素和镇痛剂。
• Methods of manufacturing injectable microgel scaffolds
  申请人：TEMPO THERAPEUTICS, INC.

  公开号：US10668185B2

  公开（公告）日：2020-06-02

  Disclosed herein are methods of manufacturing injectable microgel scaffolds, including methods of producing, purifying and concentrating microgel particles therein. The microgel scaffolds of the present disclosure are useful for a wide range of applications, such as stabilizing an implanted medical device in an implant site in a subject. The microgel scaffolds are fluidic during application and annealed or crosslinked after application to the implant site in the subject. The microgel scaffolds may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.

  本文公开了制造可注射微凝胶支架的方法，包括生产、纯化和浓缩其中微凝胶颗粒的方法。本公开的微凝胶支架可用于多种应用，例如将植入医疗设备稳定在受试者的植入部位。微凝胶支架在应用过程中是流动的，在应用到受试者的植入部位后会退火或交联。微凝胶支架中可能含有各种治疗剂，包括抗生素和镇痛剂。
• Production of Lu-177 and other radionuclides via hot atom capture on nanostructured carbon
  申请人：Board of Regents, the University of Texas System

  公开号：US11517633B2

  公开（公告）日：2022-12-06

  Described are methods for preparing radionuclides, such as radionuclides having a high specific activity. The disclosed methods include irradiating target nuclide materials, in solution, with a neutron source. The radionuclides can be separated from the target nuclide material by providing a solid carbon nanostructured material, as a suspension of solids, proximal to the target nuclide material in solution and using the recoil to drive adsorption of the radionuclide onto the solid carbon nanostructured material to transfer the radionuclides from the liquid phase (in solution) to the solid phase (adsorbed to the suspended solid carbon nanostructured material). One or more surfactants can be incorporated into the solution to facilitate formation of a stable suspension of the solid carbon nanostructured material.

  所述方法用于制备放射性核素，例如具有高比活度的放射性核素。所公开的方法包括用中子源辐照溶液中的靶核素材料。通过在溶液中的靶核素材料附近提供固体碳纳米结构材料（作为固体悬浮物），并利用反冲力将放射性核素吸附到固体碳纳米结构材料上，从而将放射性核素从液相（溶液中）转移到固相（吸附到悬浮的固体碳纳米结构材料上），从而将放射性核素从靶核素材料中分离出来。溶液中可加入一种或多种表面活性剂，以促进固体碳纳米结构材料形成稳定的悬浮液。