4-(1-吡咯烷)哌啶双盐酸盐 | 4983-39-5

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 4-(1-吡咯烷)哌啶双盐酸盐
• 中文别名: 4-吡咯烷-1-基哌啶；4-吡咯烷-1-基哌啶二盐酸盐
• 英文名称: 4-(1-Pyrrolidinyl)piperidine dihydrochloride
• 英文别名: 4-pyrrolidin-1-ylpiperidine;dihydrochloride
• CAS: 4983-39-5
• 化学式: C9H20Cl2N2
• 分子量: 227.17
• InChiKey: GRFMIOMNQWEWHQ-UHFFFAOYSA-N

物化性质

• 熔点：
  335-338 °C

计算性质

• 辛醇/水分配系数(LogP)：
  1.68
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  3
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• SUCCINOYLAMINO HETEROCYCLES AS INHIBITORS OF A-BETA PROTEIN PRODUCTION
  申请人：Bristol-Myers Squibb Pharma Company

  公开号：EP1268454A1

  公开（公告）日：2003-01-02
• [EN] SUCCINOYLAMINO HETEROCYCLES AS INHIBITORS OF A beta PROTEIN PRODUCTION<br/>[FR] HETEROCYCLES SUCCINOYLAMINO EN TANT QU'INHIBITEURS DE LA PRODUCTION DE LA BETA-PROTEINE
  申请人：DU PONT PHARM CO

  公开号：WO2001074796A1

  公开（公告）日：2001-10-11

  This invention relates to a novel succinoylamino heterocycles of Formula (I) having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.