AcPyPyβImPyPyγImPyPyβImImβDp | 938050-19-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AcPyPyβImPyPyγImPyPyβImImβDp
• 英文别名: 4-[4-[[4-[[4-[[4-[3-[[4-[(4-acetamido-1-methylpyrrole-2-carbonyl)amino]-1-methylpyrrole-2-carbonyl]amino]propanoylamino]-1-methylimidazole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]-1-methylpyrrole-2-carbonyl]amino]butanoylamino]-N-[5-[[5-[[3-[[2-[[2-[[3-[3-(dimethylamino)propylamino]-3-oxopropyl]carbamoyl]-1-methylimidazol-4-yl]carbamoyl]-1-methylimidazol-4-yl]amino]-3-oxopropyl]carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-1-methylimidazole-2-carboxamide
• CAS: 938050-19-2
• 化学式: C₇₆H₉₄N₃₀O₁₅
• 分子量: 1667.77
• InChiKey: QDDFERVREHRLMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.9
• 重原子数：
  121
• 可旋转键数：
  37
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  541
• 氢给体数：
  15
• 氢受体数：
  20

反应信息

• 作为产物：
  描述：

  N,N-二甲基-1,3-二氨基丙烷 反应 10.0h， 以9.5%的产率得到AcPyPyβImPyPyγImPyPyβImImβDp
  参考文献：
  名称：

  EP1975142

  摘要：

  公开号：

文献信息

• TOPICAL THERAPEUTIC AGENT FOR OPHTHALMIC DISEASES COMPRISING COMPOUND CAPABLE OF BINDING SPECIFICALLY TO DNA SEQUENCE
  申请人：Nagase Hiroki

  公开号：US20120071628A1

  公开（公告）日：2012-03-22

  Disclosed is a topical therapeutic agent for ophthalmic diseases, which comprises a compound capable of binding specifically to a DNA sequence. More preferably disclosed is a topical therapeutic agent for ophthalmic diseases, which comprise a pyrrole-imidazole polyamide having a specific structure. The topical therapeutic agent for ophthalmic diseases comprises a pyrrole-imidazole polyamide which can inhibit transforming growth factor-β gene and matrix metalloproteinase 9 gene.