Diethyl(4-bromphenylmercapto)-methanphosphonat | 27691-36-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: Diethyl(4-bromphenylmercapto)-methanphosphonat
• 英文别名: 1-Bromo-4-(diethoxyphosphorylmethylsulfanyl)benzene
• CAS: 27691-36-7
• 化学式: C₁₁H₁₆BrO₃PS
• 分子量: 339.19
• InChiKey: BZRDPPZLHBSQPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  60.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Diethyl(4-bromphenylmercapto)-methanphosphonat 在 oxone||potassium monopersulfate triple salt 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 14.0h， 生成 tert-butyl N-[(2E)-3-(4-bromobenzenesulfonyl)prop-2-en-1-yl]carbamate
  参考文献：
  名称：

  3-(SULPHONYL OR SULFONIMIDOYL)PROP-2-EN-1-YL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE DERIVATIVES

  摘要：

  The present invention relates to 3-(sulphonyl or sulfonimidoyl)prop-2-en-1-yl]- 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having the formula: or the pharmaceutical acceptable salt thereof. The present invention further relates to the compound according to the invention for use as a medicament and also for use in the treatment of cancer. The present invention further relates to a method for inhibiting Met1-linked ubiquitination. The present invention also relates to a pharmaceutical composition comprising the compound of the present invention.

  公开号：

  WO2023249490A1
• 作为产物：
  描述：

  对甲苯磺酰氧甲基膦酸二乙酯 、 4-溴苯硫酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以97 %的产率得到Diethyl(4-bromphenylmercapto)-methanphosphonat
  参考文献：
  名称：

  3-(SULPHONYL OR SULFONIMIDOYL)PROP-2-EN-1-YL]-2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE DERIVATIVES

  摘要：

  The present invention relates to 3-(sulphonyl or sulfonimidoyl)prop-2-en-1-yl]- 2-oxo-1,2-dihydropyridine-3-carboxamide derivatives having the formula: or the pharmaceutical acceptable salt thereof. The present invention further relates to the compound according to the invention for use as a medicament and also for use in the treatment of cancer. The present invention further relates to a method for inhibiting Met1-linked ubiquitination. The present invention also relates to a pharmaceutical composition comprising the compound of the present invention.

  公开号：

  WO2023249490A1

文献信息

• Nasser, Jamal; About-Jaudet, Elie; Collignon, Noel, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 54, # 1/4, p. 171 - 179
  作者：Nasser, Jamal、About-Jaudet, Elie、Collignon, Noel

  DOI：——

  日期：——
• Horner-Wittig Synthesis of α, β-Unsaturated Sulfides and Sulfones. Part II
  作者：I. SHAHAK、J. ALMOG

  DOI：10.1055/s-1970-21587

  日期：——
• NASSER, JAMAL;ABOUT-JAUDET, ELIE;COLLIGNON, NOEL, PHOSPH., SULFUR AND SILICON AND RELAT. ELEM., 54,(1990) N-4, C. 171-179
  作者：NASSER, JAMAL、ABOUT-JAUDET, ELIE、COLLIGNON, NOEL

  DOI：——

  日期：——