methyl 7-methoxy-3-oxo-2-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate | 1643324-01-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: methyl 7-methoxy-3-oxo-2-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate
• 英文别名: methyl 7-methoxy-3-oxo-2-phenyl-4H-1,4-benzoxazine-5-carboxylate
• CAS: 1643324-01-9
• 化学式: C₁₇H₁₅NO₅
• 分子量: 313.31
• InChiKey: OEHNELKOPNGULQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-3-(苄氧基)-5-甲氧基苯甲酸甲酯 在 吡啶 、 1,4-环己二烯 、 Pd(OH)2/C, 20% 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 methyl 7-methoxy-3-oxo-2-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate 、 methyl 2-hydroxy-7-methoxy-3-oxo-2-phenyl-3,4-dihydro-2H-benzo[b][1,4]oxazine-5-carboxylate
  参考文献：
  名称：

  Development of benzo[1,4]oxazines as biofilm inhibitors and dispersal agents against Vibrio cholerae

  摘要：

  合成了一系列天然产物启发的生物膜抑制剂库，发现了一种对霍乱弧菌具有选择性和强效抗生物膜活性的化合物。

  DOI：

  10.1039/c4cc07003h

文献信息

• Novel small molecule inhibitors of biofilm formation and the novel use of previously identified compounds for inhibition of biofilm formation and applications for drug therapy and medical device coating
  申请人：LININGTON Roger

  公开号：US20160000079A1

  公开（公告）日：2016-01-07

  Novel compounds and the novel use a class of previously identified small molecules for the inhibition of biofilm formation. Inhibition of biofilm formation can play a very important role in contributing to pathogenicity. Bacteria in the biofilm state have been shown to be 10-10,000-fold less susceptible to antibiotic treatment. Estimations made by the Centers for Disease Control (CDC) and the National Institutes of Health (NIH) attribute 65% to 80% of human infections as biofilm mediated. Consequently, biofilm formation is often responsible for chronic infections due to bacterial persistence despite antibiotic treatment.
• US9596855B2
  申请人：——

  公开号：US9596855B2

  公开（公告）日：2017-03-21