(2S,3R)-2-Allyl-3-[(S)-1-benzyl-2-oxo-2-(1H-pyrrol-2-yl)-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester | 210711-11-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,3R)-2-Allyl-3-[(S)-1-benzyl-2-oxo-2-(1H-pyrrol-2-yl)-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester
• CAS: 210711-11-8
• 化学式: C₂₈H₃₈N₂O₄
• 分子量: 466.621
• InChiKey: IOCKVOUTNKWZIS-ZDXQCDESSA-N

反应信息

• 作为反应物：
  描述：

  (2S,3R)-2-Allyl-3-[(S)-1-benzyl-2-oxo-2-(1H-pyrrol-2-yl)-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester 在 三氟乙酸 作用下， 生成 (2S,3R)-2-Allyl-3-[(S)-1-benzyl-2-oxo-2-(1H-pyrrol-2-yl)-ethylcarbamoyl]-5-methyl-hexanoic acid
  参考文献：
  名称：

  Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors

  摘要：

  A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C-terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several compounds of the series were shown to be orally bioavailable. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00597-6
• 作为产物：
  描述：

  1-O-tert-butyl 4-O-(2,3,4,5,6-pentafluorophenyl) (2S,3R)-3-(2-methylpropyl)-2-prop-2-enylbutanedioate 、 (S)-2-Amino-3-phenyl-1-(1H-pyrrol-2-yl)-propan-1-one 以 N,N-二甲基甲酰胺 为溶剂， 生成 (2S,3R)-2-Allyl-3-[(S)-1-benzyl-2-oxo-2-(1H-pyrrol-2-yl)-ethylcarbamoyl]-5-methyl-hexanoic acid tert-butyl ester
  参考文献：
  名称：

  Aryl ketones as novel replacements for the C-terminal amide bond of succinyl hydroxamate MMP inhibitors

  摘要：

  A series of succinyl hydroxamate MMP inhibitors were prepared incorporating an aryl amino ketone moiety in place of the more typical C-terminal amino acid amides. Compounds of the C-terminal ketone series displayed potent inhibition of MMPs. Several compounds of the series were shown to be orally bioavailable. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00597-6