5'-O-acetyl-2',3'-dideoxy-4'-C-methyluridine | 175545-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5'-O-acetyl-2',3'-dideoxy-4'-C-methyluridine
• CAS: 175545-32-1
• 化学式: C₁₂H₁₆N₂O₅
• 分子量: 268.269
• InChiKey: QPPMYDVWBZTVRQ-PWSUYJOCSA-N

反应信息

• 作为反应物：
  描述：

  5'-O-acetyl-2',3'-dideoxy-4'-C-methyluridine 在 ammonium hydroxide 、 ClPhPOCl₂ 作用下， 以 吡啶 为溶剂， 生成 2',3'-dideoxy-4'-C-methylcytidine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of 4′-C-Methyl Nucleosides

  摘要：

  A series of 2'-deoxy, 2',3'-unsaturated and 2',3'-dideoxynucleoside analogues, which have an additional methyl group at the 4'-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2'-deoxy-4'-C-methyl nucleosides exhibited potent activity.

  DOI：

  10.1080/07328319608002385
• 作为产物：
  描述：

  Acetic acid (2S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-methyl-2,5-dihydro-furan-2-ylmethyl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 5'-O-acetyl-2',3'-dideoxy-4'-C-methyluridine
  参考文献：
  名称：

  Synthesis and Biological Evaluation of 4′-C-Methyl Nucleosides

  摘要：

  A series of 2'-deoxy, 2',3'-unsaturated and 2',3'-dideoxynucleoside analogues, which have an additional methyl group at the 4'-position, have been synthesized. When evaluated for their inhibitory activity against HIV in MT-4 cell, 2'-deoxy-4'-C-methyl nucleosides exhibited potent activity.

  DOI：

  10.1080/07328319608002385