| 192652-94-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 192652-94-1
• 化学式: C₂₄H₃₀N₆O₈
• 分子量: 530.538
• InChiKey: OAEHLJASNLQOHM-GRUVHVDGSA-N

反应信息

• 作为反应物：
  描述：

  在 吡啶 、 二异丙基铵盐四氮唑 作用下， 以 二氯甲烷 为溶剂， 反应 32.0h， 生成
  参考文献：
  名称：

  Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: the effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

  摘要：

  Thymidine dinucleotide analogs with imidazole-derived backbones (III and IV) were synthesized. These modified dimeric building blocks were incorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined and compared to the corresponding olefinic modifications I and II. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00270-9
• 作为产物：
  描述：

  3-Benzyloxymethyl-1-[(2R,4S,5R)-4-(tert-butyl-diphenyl-silanyloxy)-5-vinyl-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione 在 palladium on activated charcoal 吡啶 、 盐酸 、 4-二甲氨基吡啶 、 sodium hydroxide 、 9-borabicyclo[3.3.1]nonane dimer 、 氢气 、 双氧水 、 sodium hydride 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 80.0h， 生成
  参考文献：
  名称：

  Replacement of the phosphodiester linkage in oligonucleotides by heterocycles: the effect of triazole- and imidazole-modified backbones on DNA/RNA duplex stability

  摘要：

  Thymidine dinucleotide analogs with imidazole-derived backbones (III and IV) were synthesized. These modified dimeric building blocks were incorporated into oligodeoxyribonucleotides. The hybridization affinity of the modified oligonucleotides for RNA complements was determined and compared to the corresponding olefinic modifications I and II. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00270-9