Acrylsaeure-(3-chlor-2,2-bis-chlormethyl-propylester) | 3217-35-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acrylsaeure-(3-chlor-2,2-bis-chlormethyl-propylester)
• 英文别名: [3-Chloro-2,2-bis(chloromethyl)propyl] prop-2-enoate
• CAS: 3217-35-4
• 化学式: C₈H₁₁Cl₃O₂
• 分子量: 245.533
• InChiKey: OGHHKLNFBZRBOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 3-氯-2,2-二(氯甲基)丙-1-醇 以68%的产率得到
  参考文献：
  名称：

  KORSHUNOV, M. A.;KUZOVLEVA, R. G.;KARTASHOVA, N. N., OSNOV. ORGAN. SINTEZ I NEFTEXIMIYA, YAROSLAVL, 1981, N 15, 36-40

  摘要：

  DOI：

文献信息

• DENTAL MUCOSAL ADJUSTMENT MATERIAL
  申请人：TOKUYAMA CORPORATION

  公开号：EP1857094A1

  公开（公告）日：2007-11-21

  A mucosal adjustment material comprising a combination of a powdery material (a) and a liquid material (b), characterized especially in that a noncrosslinked (meth)acrylic polymer powder having a Tg in the range of 0-60 DEG C, e.g., polybutyl methacrylate, is used as the powdery material and a liquid polymer which has a mass-average molecular weight of 1,000-10,000 and in which the content of oligomers having a molecular weight of 500 or lower is 10 mass% or lower is used as the liquid material. Such powdery material and liquid material are kneaded together to prepare a paste, which is applied to a denture base and used as a temporary relining material. This mucosal adjustment material in a paste form is reduced in the amount of ingredients eluted from the material during use in the mouth. In an ordinary use period, the relining material retains its initial flexibility and does not deteriorate the denture base.

  一种由粉末状材料（a）和液体材料（b）组合而成的粘膜调节材料，其特征在于粉末状材料使用 Tg 在 0-60 摄氏度范围内的非交联（甲基）丙烯酸聚合物粉末，例如聚甲基丙烯酸丁酯；液体材料使用质量平均分子量在 1,000-10,000 之间的液体聚合物，其中分子量在 500 或以下的低聚物含量在 10 质量%或以下。将粉末状材料和液体材料揉捏在一起，制成糊状，涂抹在义齿基托上，用作临时衬垫材料。这种糊状的粘膜调整材料在口腔中使用时，材料中的洗脱成分会减少。在正常使用期间，衬垫材料保持其最初的柔韧性，不会损坏义齿基托。
• Responsive microgel and methods related thereto
  申请人：——

  公开号：US20030152623A1

  公开（公告）日：2003-08-14

  A responsive microgel is provided which responds volumetrically and reversibly to a change in one or more aqueous conditions selected from the group consisting of (temperature, pH, and ionic conditions) comprised of an ionizable network of covalently cross-linked homopolymeric ionizable monomers wherein the ionizable network is covalently attached to an amphiphilic copolymer to form a plurality of ‘dangling chains’ and wherein the ‘dangling chains’ of amphiphilic copolymer form immobile micelle-like aggregates in aqueous solution. A responsive microgel is further provided that comprises at least one therapeutic entity and delivers a substantially linear and sustained release of the therapeutic entity under physiological conditions.

  本发明提供了一种响应型微凝胶，该微凝胶可对选自由温度、pH 值和离子条件组成的组中的一种或多种水性条件的变化作出体积上和可逆的响应、和离子条件）组成的共价交联均聚可离子化单体的可离子化网络，其中可离子化网络与两性共聚物共价连接，形成多条 "悬链"，两性共聚物的 "悬链 "在水溶液中形成不动的胶束状聚集体。还提供了一种响应性微凝胶，它包含至少一种治疗实体，并能在生理条件下提供治疗实体的线性和持续释放。
• Dental mucosal adjustment material
  申请人：Tokuyama Corporation

  公开号：EP1857094B1

  公开（公告）日：2014-04-23
• RESPONSIVE MICROGEL AND METHODS RELATED THERETO
  申请人：SUPRATEK PHARMA, INC.

  公开号：EP1478403A1

  公开（公告）日：2004-11-24
• CONTROL OF SUSTAINED CASING PRESSURE IN WELLBORE ANNULI
  申请人：Albemarle Corporation

  公开号：EP3087155A1

  公开（公告）日：2016-11-02