(3S)-3-Hydroxy-3-methylhexanoic acid | 757219-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (3S)-3-Hydroxy-3-methylhexanoic acid
• CAS: 757219-38-8
• 化学式: C₇H₁₄O₃
• 分子量: 146.18
• InChiKey: RGRNSTGIHROKJB-ZETCQYMHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• C-19 STEROIDS FOR COSMETIC AND FURTHER USES
  申请人：WINDISCH Martin

  公开号：US20100256102A1

  公开（公告）日：2010-10-07

  The present invention relates to novel uses of C-19 steroid compounds, in particular C-19 steroids having an androsten-17-(OR 4 )-3-one structure for cosmetic and further uses, wherein R 4 is hydrogen or an unsubstituted or substituted alkyl, aryl, acyl or any group leading to hydroxyl upon biological metabolization or chemical deprotection. The present invention particularly relates to selected C-19 steroids displaying properties of high binding affinity to androgen receptor to block dihydrotestosterone from binding, while at the same time providing anabolic effects, which is useful for certain applications, particularly for influencing or controlling problems of the skin and its skin-associated body structures like cellulite, wrinkles, adipose fat tissues, hair follikles or hair growth; for influencing or controlling gland function and activity such as the sebaceous gland and other glands affecting the skin and/or perspiration. The present invention also describes a composition comprising a combination of such a compound and dimethyl isosorbide.

  本发明涉及C-19类固醇化合物的新用途，特别是具有雄甾-17-(OR4)-3-酮结构的C-19类固醇用于化妆品和其他用途，其中R4是氢或未取代或取代的烷基，芳基，酰基或任何在生物代谢或化学去保护后导致羟基的基团。本发明特别涉及选择的C-19类固醇，其具有高结合亲和力，可阻止二氢睾酮结合，同时提供肌肉增长效果，这对于某些应用特别有用，特别是用于影响或控制皮肤及其皮肤相关结构的问题，如脂肪团、皱纹、脂肪组织、毛发囊或毛发生长；用于影响或控制腺体功能和活动，如皮脂腺和其他影响皮肤和/或出汗的腺体。本发明还描述了一种组合了这种化合物和二甲基异山梨醇的组合物。
• PSEUDO BODY ODOR COMPOSITION
  申请人：Takasago International Corporation

  公开号：EP1601338B1

  公开（公告）日：2011-07-06
• US8258123B2
  申请人：——

  公开号：US8258123B2

  公开（公告）日：2012-09-04