(2R)-2-amino-3-(3-methylbut-2-enylsulfanyl)propanoic acid;hydrochloride | 1268386-24-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-amino-3-(3-methylbut-2-enylsulfanyl)propanoic acid;hydrochloride
• CAS: 1268386-24-8
• 化学式: C₈H₁₅NO₂S*ClH
• 分子量: 225.74
• InChiKey: SLVHUKDQNMTUIZ-FJXQXJEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.52
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  88.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲基-3-丁烯-2-醇 、 L-半胱氨酸盐酸盐无水物 在 ruthenium(1+), (ϖ(5)-2,4-cyclopentadien-1-yl)(ϖ(3)-2-propen-1-yl)(2-quinolinecarboxylato-N1,O2)-, hexafluorophosphate(1-) 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 (2R)-2-amino-3-(3-methylbut-2-enylsulfanyl)propanoic acid;hydrochloride 、 (2R)-2-amino-3-(2-methylbut-3-en-2-ylsulfanyl)propanoic acid;hydrochloride
  参考文献：
  名称：

  Catalytic Dehydrative S-Allylation of Cysteine-Containing Peptides in Aqueous Media toward Lipopeptide Chemistry

  摘要：

  Thiol-containing peptides and cysteine have been successfully S-allylated with various ally! alcohols in aqueous medium containing a catalytic amount of [CpRu-(eta(3)-C(3)H(5))(2-quinolinecarboxylato)]PF(6). Quick and easy install of 2-propen-l-ol having a long-chain alkyl group at C(2) facilitates the synthesis of a new series of artificial lipopeptides, indicating a potential application to synthetic biology.

  DOI：

  10.1021/jo102278m

文献信息

• Catalytic Dehydrative <i>S</i>-Allylation of Cysteine-Containing Peptides in Aqueous Media toward Lipopeptide Chemistry
  作者：Parasuraman Jaisankar、Shinji Tanaka、Masato Kitamura

  DOI：10.1021/jo102278m

  日期：2011.3.18

  Thiol-containing peptides and cysteine have been successfully S-allylated with various ally! alcohols in aqueous medium containing a catalytic amount of [CpRu-(eta(3)-C(3)H(5))(2-quinolinecarboxylato)]PF(6). Quick and easy install of 2-propen-l-ol having a long-chain alkyl group at C(2) facilitates the synthesis of a new series of artificial lipopeptides, indicating a potential application to synthetic biology.