d-beta-Homoglutamine | 1263046-59-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: d-beta-Homoglutamine
• 英文别名: (3R)-3,6-diamino-6-oxohexanoic acid
• CAS: 1263046-59-8
• 化学式: C₆H₁₂N₂O₃
• 分子量: 160.17
• InChiKey: IDNSGZOFDGAHTI-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] PROCESS FOR THE PURIFICATION OF FACTOR VII POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS<br/>[FR] PROCÉDÉ DE PURIFICATION DE POLYPEPTIDES DE FACTEUR VII À L'AIDE DE RÉSINES D'AFFINITÉ COMPORTANT DES LIGANDS SPÉCIFIQUES
  申请人：NOVO NORDISK AS

  公开号：WO2009141384A2

  公开（公告）日：2009-11-26

  The invention concerns a process for the purification of a drug substance of a Factor VII polypeptide, said process comprising the steps of: (a) contacting the drug substance with an affinity resin under conditions which facilitate binding of a portion of said drug substance to said affinity resin; (b) optionally washing said affinity resin containing bound drug substance with a washing buffer; and (c) eluting said affinity resin containing bound drug substance with an elution buffer, and collecting a purified drug substance of the Factor VII polypeptide as an eluate; wherein said affinity resin is a solid phase material having covalently immobilized thereto one or more ligands of the general formula (I), wherein each of R1, R2 and R3 represents an organic moiety of a molecular weight of 15-1000 g/mol, the total molecular weight of said ligand being 200- 2000 g/mol; said ligand being immobilized to said solid phase material via one of said organic moieties R1, R2 and R3.