4-Mercapto-indol | 89942-89-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-Mercapto-indol
• 英文别名: 1H-indole-4-thiol
• CAS: 89942-89-2
• 化学式: C₈H₇NS
• mdl: MFCD19221945
• 分子量: 149.216
• InChiKey: VKOPZHDWHPNIIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  16.8
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION
  申请人：Cleave Biosciences, Inc.

  公开号：US20140235548A1

  公开（公告）日：2014-08-21

  Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.

  本文介绍了化合物、药物组合物以及使用这些化合物治疗或预防与JAMM蛋白相关或介导的疾病或障碍的方法。这些化合物和组合物抑制JAMM域的酶活性，包括COP9信号体（CSN）的CSN5亚基的JAMM域、26S蛋白酶的Rpn11/Poh1/Psmd14亚基的JAMM域、AMSH的JAMM域、AMSH-LP的JAMM域、BRCC36的JAMM域等其他JAMM域。
• QUINAZOLINE AND INDOLE COMPOUNDS TO TREAT MEDICAL DISORDERS
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：EP3939591A1

  公开（公告）日：2022-01-19

  Compounds, methods of use, and processes for making inhibitors of Complement Factor B are provided.

  本研究提供了用于制造补体因子 B 抑制剂的化合物、使用方法和工艺。
• JPS62132857A
  申请人：——

  公开号：JPS62132857A

  公开（公告）日：1987-06-16
• [EN] COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION<br/>[FR] COMPOSITION ET PROCÉDÉS POUR L'INHIBITION DES PROTÉINES JAMM
  申请人：ZHOU HAN-JIE

  公开号：WO2012158435A1

  公开（公告）日：2012-11-22

  Compounds, pharmaceutical compositions, and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by JAMM proteins are disclosed. The compounds and compositions inhibit the enzymatic activity of a JAMM domain, including the JAMM domain of the CSN5 subunit of the COP9-signalsome (CSN), the JAMM domain of the Rpn11/Poh1/Psmd14 subunit of the 26S proteasome, the JAMM domain of AMSH, the JAMM domain of AMSH-LP, the JAMM domain of BRCC36, among other JAMM domains.