(2S)-2,6-diamino-N-[(1S,3R,4S,5R,6S,9R,10S)-1-amino-4,5,9,10-tetrahydroxy-7-oxaspiro[5.6]dodecan-3-yl]hexanamide | 1261084-84-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2,6-diamino-N-[(1S,3R,4S,5R,6S,9R,10S)-1-amino-4,5,9,10-tetrahydroxy-7-oxaspiro[5.6]dodecan-3-yl]hexanamide
• CAS: 1261084-84-7
• 化学式: C₁₇H₃₄N₄O₆
• 分子量: 390.48
• InChiKey: QEAGMRJMUFPDHD-HCZZMEHVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  197
• 氢给体数：
  8
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 溶剂黄146 、 1,3-环己二烯 作用下， 反应 4.0h， 以68%的产率得到(2S)-2,6-diamino-N-[(1S,3R,4S,5R,6S,9R,10S)-1-amino-4,5,9,10-tetrahydroxy-7-oxaspiro[5.6]dodecan-3-yl]hexanamide
  参考文献：
  名称：

  Second generation analogs of rigid 6,7-spiro scaffolds targeting the bacterial ribosome

  摘要：

  Previous work from our group described the synthesis and biological evaluation of new rigid, 6,6- and 6,7-spiro aminoglycosidic scaffolds targeting the bacterial ribosome. Herein we describe an improved synthetic protocol for their construction, and extend our study by further amino-functionalization of their 6,7-spiro analogs. The synthetic strategy, preparation and evaluation of some representative examples are reported. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.10.001