1-(2-morpholin-4-ylphenyl)ethanone O-methyloxime | 874993-78-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1-(2-morpholin-4-ylphenyl)ethanone O-methyloxime
• 英文别名: N-methoxy-1-(2-morpholin-4-ylphenyl)ethanimine
• CAS: 874993-78-9
• 化学式: C₁₃H₁₈N₂O₂
• 分子量: 234.298
• InChiKey: QUMOWFPFLPCUFF-UHFFFAOYSA-N

物化性质

• 沸点：
  358.6±52.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-morpholin-4-ylphenyl)ethanone O-methyloxime 在 盐酸 作用下， 以 乙醚 为溶剂， 反应 0.08h， 以100%的产率得到1-(2-morpholinophenyl)ethan-1-one O-methyl oxime hydrochloride
  参考文献：
  名称：

  Rhodium(III)-Catalyzed Intermolecular Direct Amination of Aromatic C–H Bonds withN-Chloroamines

  摘要：

  A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol Involving In situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

  DOI：

  10.1021/ol203046n
• 作为产物：
  描述：

  苯乙酮 在 silver hexafluoroantimonate 、 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 cesium acetate 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 19.08h， 生成 1-(2-morpholin-4-ylphenyl)ethanone O-methyloxime
  参考文献：
  名称：

  Rhodium(III)-Catalyzed Intermolecular Direct Amination of Aromatic C–H Bonds withN-Chloroamines

  摘要：

  A Rh(III)-catalyzed direct aromatic C-H amination is achieved using N-chloroamines as a reagent. Furthermore, we also developed a one-pot amination protocol Involving In situ chlorination of the secondary amines. The catalytic amination operates at mild conditions with excellent functional group tolerance and regioselectivity.

  DOI：

  10.1021/ol203046n

文献信息

• Cyanoamidine P2X7 antagonists for the treatment of pain
  申请人：Carroll A. William

  公开号：US20060025614A1

  公开（公告）日：2006-02-02

  Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R 1 -R 12 are as defined in the specification act as antagonists of the P2X 7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

  新型氰胺基化合物的化学式(I)和(II)及其衍生物，其中R1-R12如规范中定义的作为P2X7受体的拮抗剂。这些化合物在治疗疼痛、炎症和神经退行性状态方面特别有用。
• Rh-Catalyzed Intermolecular Carbenoid Functionalization of Aromatic C–H Bonds by α-Diazomalonates
  作者：Wai-Wing Chan、Siu-Fung Lo、Zhongyuan Zhou、Wing-Yiu Yu

  DOI：10.1021/ja305771y

  日期：2012.8.22

  A Rh-catalyzed intermolecular coupling of diazomalonates with arene C-H bonds is reported. The reaction is initiated by electrophilic C-H activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross-couple with diazomalonates with excellent regioselectivities and functional

  报道了重氮丙二酸酯与芳烃 CH 键的 Rh 催化分子间偶联。该反应由亲电 CH 活化引发，随后是芳基铑 (III) 配合物与重氮丙二酸酯的偶联。在大多数情况下，以肟、羧酸和胺为导向基团的芳烃与具有优异区域选择性和官能团耐受性的重氮丙二酸酯交叉偶联，因此，该反应为特定应用的 α-芳基羰基化合物提供了一条新途径。
• Cyanoamidine P2X7 Antagonists for the Treatment of Pain
  申请人：Carroll A. William

  公开号：US20070232686A1

  公开（公告）日：2007-10-04

  Novel cyanoamidines compounds of formula (I) and (II) and their derivatives wherein R 1 -R 12 are as defined in the specification act as antagonists of the P2X 7 receptor. These compounds are particularly useful in the treatment of pain, inflammation and neurodegeneration states.

  化合物(I)和(II)以及它们的衍生物，其化学式中R1-R12如规范中定义，可作为P2X7受体的拮抗剂。这些化合物在治疗疼痛、炎症和神经退行性疾病方面特别有用。