Chloromethyl-dimethyl-(thiophen-2-ylmethyl)silane | 187337-31-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: Chloromethyl-dimethyl-(thiophen-2-ylmethyl)silane
• CAS: 187337-31-1
• 化学式: C₈H₁₃ClSSi
• 分子量: 204.796
• InChiKey: LTXPADYNHSJRMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.32
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯甲醛 、 Chloromethyl-dimethyl-(thiophen-2-ylmethyl)silane 在 magnesium 作用下， 生成 2-[Dimethyl(thiophen-2-ylmethyl)silyl]-1-phenylethanol
  参考文献：
  名称：

  Synthesis of Thiophene Derivatives Bearing a Silicon Atom

  摘要：

  Synthesis of thiophene derivatives containing a silicon atom is described. Silylation of 2-thienylmethyl chloride (12) with trichlorovinylsilane or chloro(chloromethyl)dimethylsilane was accomplished by addition of 12 to a mixture of Mg and the former reagent in THF or by addition of a mixture of 12 and the latter reagent to a mixture of Mg in THF to give dichloro(2-thienylmethyl)vinylsilane (13) or chloromethyl(dimethyl)(2-thienylmethyl) (18). The Grignard reagent (19) of 18 reacted with carbon dioxide, dimethyl carbonate or benzaldehyde to produce dimethyl(2-thienylmethyl)silylacetic acid (20), methyl dimethyl(2-thienylmethyl)silylacetate (21) or 2'-[dimethyl(2-thienylmethyl)silyl]-1'-phenylethanol (22).

  DOI：

  10.3987/com-96-s51
• 作为产物：
  描述：

  2-噻吩甲醇 在 吡啶 、 氯化亚砜 、 碘 、 magnesium 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.17h， 生成 Chloromethyl-dimethyl-(thiophen-2-ylmethyl)silane
  参考文献：
  名称：

  Synthesis of Thiophene Derivatives Bearing a Silicon Atom

  摘要：

  Synthesis of thiophene derivatives containing a silicon atom is described. Silylation of 2-thienylmethyl chloride (12) with trichlorovinylsilane or chloro(chloromethyl)dimethylsilane was accomplished by addition of 12 to a mixture of Mg and the former reagent in THF or by addition of a mixture of 12 and the latter reagent to a mixture of Mg in THF to give dichloro(2-thienylmethyl)vinylsilane (13) or chloromethyl(dimethyl)(2-thienylmethyl) (18). The Grignard reagent (19) of 18 reacted with carbon dioxide, dimethyl carbonate or benzaldehyde to produce dimethyl(2-thienylmethyl)silylacetic acid (20), methyl dimethyl(2-thienylmethyl)silylacetate (21) or 2'-[dimethyl(2-thienylmethyl)silyl]-1'-phenylethanol (22).

  DOI：

  10.3987/com-96-s51