N-boc-3-(4-piperidyl)isocoumarin | 1240426-29-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异香豆素及其衍生物
• 英文名称: N-boc-3-(4-piperidyl)isocoumarin
• 英文别名: tert-butyl 4-(1-oxoisochromen-3-yl)piperidine-1-carboxylate
• CAS: 1240426-29-2
• 化学式: C₁₉H₂₃NO₄
• 分子量: 329.396
• InChiKey: ASIWOUYNLPBHNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-boc-3-(4-piperidyl)isocoumarin 在 氨 作用下， 以 甲醇 为溶剂， 以96%的产率得到N-Boc-3-(4-piperidyl)isoquinolin-1-one
  参考文献：
  名称：

  Synthesis of 7-(4-piperidyl)- [1,6]naphthyridin-5-one and 3-(4-piperidyl)isoqunolin-1-one

  摘要：

  7-(4-Piperidyl)[1,6] napththiridin-5-one was synthesized on the basis of 2-methylnicotinic acid. 3-(4-Piperidyl) isoquinolin-1-one was synthesized from the diethylamide of o-toluic acid and Weinreb's amide of N-Boc-isonipecotic acid.

  DOI：

  10.1007/s10593-010-0457-6
• 作为产物：
  描述：

  tert-butyl 4-(2-(2-(diethylcarbamoyl)phenyl)acetyl)piperidine-1-carboxylate 在 溶剂黄146 作用下， 以 甲苯 为溶剂， 生成 N-boc-3-(4-piperidyl)isocoumarin
  参考文献：
  名称：

  Synthesis of 7-(4-piperidyl)- [1,6]naphthyridin-5-one and 3-(4-piperidyl)isoqunolin-1-one

  摘要：

  7-(4-Piperidyl)[1,6] napththiridin-5-one was synthesized on the basis of 2-methylnicotinic acid. 3-(4-Piperidyl) isoquinolin-1-one was synthesized from the diethylamide of o-toluic acid and Weinreb's amide of N-Boc-isonipecotic acid.

  DOI：

  10.1007/s10593-010-0457-6

文献信息

• Synthesis of 7-(4-piperidyl)- [1,6]naphthyridin-5-one and 3-(4-piperidyl)isoqunolin-1-one
  作者：D. A. Kovalskiy、V. P. Perevalov

  DOI：10.1007/s10593-010-0457-6

  日期：2009.12

  7-(4-Piperidyl)[1,6] napththiridin-5-one was synthesized on the basis of 2-methylnicotinic acid. 3-(4-Piperidyl) isoquinolin-1-one was synthesized from the diethylamide of o-toluic acid and Weinreb's amide of N-Boc-isonipecotic acid.