2-(4,6-difluoro-1H-indol-3-yl)ethanamine | 1360891-65-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-(4,6-difluoro-1H-indol-3-yl)ethanamine
• CAS: 1360891-65-1
• 化学式: C₁₀H₁₀F₂N₂
• 分子量: 196.2
• InChiKey: XGDPOURMTUKZDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  41.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS AND METHODS FOR THE MODULATION OF AhR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA MODULATION D'AHR
  申请人：IDEAYA BIOSCIENCES INC

  公开号：WO2019156989A1

  公开（公告）日：2019-08-15

  Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: (I) wherein the letters and symbols a, b, c, d, e, f, A, R1, X1, Ar1 and Ar2 have the meanings provided in the specification.

  本文提供了化合物、组合物及使用这些化合物和组合物治疗部分受AhR调控的疾病的方法。这些化合物用以下式表示：（I），其中字母和符号a、b、c、d、e、f、A、R1、X1、Ar1和Ar2的含义在规范中提供。
• Substituted imidazo[1,5-a]pyrazines and [1,2,4]triazolo[4,3-a]pyrazines for the modulation of AhR
  申请人：IDEAYA BIOSCIENCES, INC.

  公开号：US11530220B2

  公开（公告）日：2022-12-20

  Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R 1 , X 1 , Ar 1 and Ar 2 have the meanings provided in the specification.

  本文提供了用于治疗至少部分受 AhR 调节的疾病的化合物、组合物和使用这些化合物和组合物的方法。这些化合物用式表示： 其中字母和符号 a、b、c、d、e、f、A、R 1 , X 1 Ar 1 和 Ar 2 具有说明书中规定的含义。
• COMPOUNDS AND METHODS FOR THE MODULATION OF AHR
  申请人：IDEAYA BIOSCIENCES, INC.

  公开号：US20210079001A1

  公开（公告）日：2021-03-18

  Provided herein are compounds, compositions and methods of using the compounds and compositions for the treatment of diseases modulated, as least in part, by AhR. The compounds are represented by formula: wherein the letters and symbols a, b, c, d, e, f, A, R 1 , X 1 , Ar 1 and Ar 2 have the meanings provided in the specification.