pentylamine acetate | 64370-74-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: pentylamine acetate
• 英文别名: Pentylazanium;acetate；pentylazanium;acetate
• CAS: 64370-74-7
• 化学式: C₂H₄O₂*C₅H₁₃N
• 分子量: 147.217
• InChiKey: CZDSWGSBWBDBQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.23
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  pentylamine acetate 、 双去甲氧基姜黄素 在 Montmorillonite K-10 作用下， 反应 0.02h， 以23%的产率得到2-(4-hydroxyphenyl)-6-[(E)-2-(4-hydroxyphenyl)ethenyl]-1-pentyl-2,3-dihydropyridin-4-one
  参考文献：
  名称：

  Synthesis of novel 2,3-dihydro-4-pyridinones from bisdemethoxycurcumin under microwave irradiation

  摘要：

  A novel synthesis of 2,3-dihydro-4-pyridinones via the reaction of bisdemethoxycurcumin and primary amines or amine acetates is demonstrated. The structures of the products were established by elemental analysis and from mass, H-1 and C-13 NMR spectra. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.115
• 作为产物：
  描述：

  1-氨基戊烷 、 溶剂黄146 以 乙醚 为溶剂， 生成 pentylamine acetate
  参考文献：
  名称：

  氧化还原介导的连苯三酚基多酚的胺化

  摘要：

  已知淀粉样蛋白可通过胺化作用被天然多酚修饰。本研究采用体外和计算机方法研究了多酚和N -亲核试剂之间的氧化偶联机制。结果表明，具有连苯三酚亚结构和 C4a 位吸电子基团的多酚最有效。这些见解可以在抗淀粉样蛋白生成的药物设计中发挥至关重要的作用。

  DOI：

  10.1002/chem.202303783

文献信息

• Protic ionic liquids (PILs) nanostructure and physicochemical properties: development of high-throughput methodology for PIL creation and property screens
  作者：Tamar L. Greaves、Krystal Ha、Benjamin W. Muir、Shaun C. Howard、Asoka Weerawardena、Nigel Kirby、Calum J. Drummond

  DOI：10.1039/c4cp04241g

  日期：——

  A high-throughput approach was developed in order to prepare and dry a series of protic ionic liquids (PILs) from 48 Brønsted acid–base combinations.

  为了制备和干燥一系列的质子离子液体（PILs），开发了一种高通量方法，可以从48种Brønsted酸碱组合中制备。
• [EN] DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS<br/>[FR] ANTAGONISTES DIARYLALKYLAMINES DE REV-ERB ET LEUR UTILISATION COMME MÉDICAMENTS
  申请人：FOND ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：WO2015052283A1

  公开（公告）日：2015-04-16

  The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof : It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.

  本发明涉及式（I）的化合物或其药用可接受的盐或溶剂：还揭示了一种包括式（I）化合物的药物组合物，以及它们作为抗增殖和促凋亡剂用于癌症治疗的用途。
• DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS
  申请人：FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

  公开号：US20160237057A1

  公开（公告）日：2016-08-18

  The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.

  本发明涉及式（I）的化合物或其药学上可接受的盐或溶剂：它进一步揭示了包含式（I）化合物的制药组合物以及它们作为抗增殖和促凋亡剂用于癌症治疗的用途。
• Method of staining, detecting and counting bacteria, and a diluent for bacterial stain
  申请人：Sysmex Corporation

  公开号：EP1203825A2

  公开（公告）日：2002-05-08

  A method of staining bacteria comprises: working a polymethine dye on a sample in the presence of a substance capable of reducing nitrite ions to stain bacteria in the sample. A method of detecting bacteria comprises the following steps of: (1) working a polymethine dye on a sample by a method as described above to stain bacteria in the sample, (2) introducing the thus treated sample into a detecting part of a flow cytometer and irradiating cells of the stained bacteria one by one with light to measure scattered light and fluorescent light emitted from each of the cells; and (3) discriminating the bacteria from other components in accordance with an intensity of a scattered light signal and an intensity of a fluorescent light signal or a pulse width reflecting the length of particles to count the bacteria.

  一种对细菌染色的方法包括：在有能还原亚硝酸根离子的物质存在的情况下，将聚甲基染料作用于样品，对样品中的细菌进行染色。一种检测细菌的方法包括以下步骤：(1)用上述方法在样品上加工聚甲胺染料，使样品中的细菌染色；(2)将这样处理过的样品引入流式细胞仪的检测部分，用光逐个照射被染色细菌的细胞，测量每个细胞发出的散射光和荧光；(3)根据散射光信号的强度和荧光信号的强度或反映颗粒长度的脉冲宽度，将细菌与其他成分区分开来，对细菌进行计数。
• Sample analyzers, bacteria analyzers, and solutions for diluting and cleaning
  申请人：Sysmex Corporation

  公开号：EP1413889A2

  公开（公告）日：2004-04-28

  Sample analyzers for analyzing a sample are described that include a pipette for suctioning the sample; a sample preparation unit for preparing a measured sample by diluting the sample supplied by the pipette with an acidic solution; a pipette washing unit for washing the pipette with the acidic solution; a detection unit for obtaining a detection signal from the measured sample prepared by the sample preparation unit; and a controller for calculating an analysis result from the detection signal obtained by the detection unit. Bacteria analyzers for analyzing bacteria and solutions for use in sample analyzers are also described.

  描述了用于分析样品的样品分析仪，其中包括：用于抽吸样品的移液管；通过用酸性溶液稀释移液管提供的样品来制备测量样品的样品制备单元；用酸性溶液清洗移液管的移液管清洗单元；从样品制备单元制备的测量样品中获取检测信号的检测单元；以及根据检测单元获取的检测信号计算分析结果的控制器。此外，还介绍了用于分析细菌的细菌分析仪和用于样品分析仪的溶液。