Z-FR-Amc

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-FR-Amc
• 英文别名: benzyl N-[1-[[5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate;hydrochloride
• 化学式: C33H37ClN6O6
• 分子量: 649.1
• InChiKey: NXIWJKWURGALDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.54
• 重原子数：
  46
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  187
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• COMPOSITIONS AND METHODS FOR MODULATING VIRAL INFECTIONS BY REGULATING GLUCOSYLCERAMIDES
  申请人：University of Virginia Patent Foundation

  公开号：EP3934688A1

  公开（公告）日：2022-01-12
• [EN] COMPOSITIONS AND METHODS FOR MODULATING VIRAL INFECTIONS BY REGULATING GLUCOSYLCERAMIDES<br/>[FR] COMPOSITIONS ET MÉTHODES DE MODULATION D'INFECTIONS VIRALES PAR RÉGULATION DE GLUCOSYLCÉRAMIDES
  申请人：UNIV VIRGINIA PATENT FOUNDATION

  公开号：WO2020185675A1

  公开（公告）日：2020-09-17

  Provided are methods and compositions for inhibiting viral infections. In some embodiments, the methods include administering to a subject infected with and/or at risk for infection with a virus a composition having a glucosylceramidase inhibitor, a glucosylceramide synthase inhibitor, or any combination thereof via a route and in an amount effective for treating and/or inhibiting the viral infection in the subject. Also provided are methods for inhibiting viral infections of cells, methods for inhibiting endosomal fusion of viruses in cells, and compositions for use in treating and/or inhibiting viral infections of subjects and/or cells.