3-(1-cyclopropylmethyl-6,8-dimethoxy-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide | 923958-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 3-(1-cyclopropylmethyl-6,8-dimethoxy-2-oxo-7-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzamide
• 英文别名: 3-[1-(cyclopropylmethyl)-6,8-dimethoxy-2-oxo-7-phenyl-3H-1,4-benzodiazepin-5-yl]benzamide
• CAS: 923958-07-0
• 化学式: C₂₈H₂₇N₃O₄
• 分子量: 469.54
• InChiKey: PICGXCDUCSZUJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  94.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Benzodiazepine derivatives, their preparation and the therapeutic use thereof
  申请人：NEURO3D

  公开号：EP1749824A1

  公开（公告）日：2007-02-07

  The invention relates to benzodiazepine derivatives having PDE2 inhibitory activities, as well as therapeutic methods by administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. It further deals with pharmaceutical compositions comprising said compounds and methods for preparing said compounds.

  本发明涉及具有PDE2抑制活性的苯二氮平衍生物，以及通过给予该化合物的治疗方法，特别是用于治疗中枢或外周神经系统的各种疾病。它还涉及包含该化合物的制药组合物和制备该化合物的方法。
• Compounds, preparation and therapeutic use thereof
  申请人：Abarghaz Mustapha

  公开号：US20090215752A1

  公开（公告）日：2009-08-27

  The invention relates to benzodiazepine derivatives having PDE2 inhibitory activities, as well as therapeutic methods of administering said compounds, in particular for treating various diseases of the central or peripheral nervous system. The invention further includes methods of preparing the subject compounds and pharmaceutical compositions containing them.

  本发明涉及具有PDE2抑制活性的苯二氮平衍生物，以及给予所述化合物的治疗方法，特别是用于治疗中枢或外周神经系统的各种疾病。本发明还包括制备所述化合物的方法和包含它们的制药组合物。
• Automobile interior or exterior trim material
  申请人：ASAHI DENKA KOGYO KABUSHIKI KAISHA

  公开号：EP0953596A2

  公开（公告）日：1999-11-03

  An automobile interior or exterior trim material which is formed of a thermoplastic elastomer composition containing 100 parts by weight of a thermoplastic elastomer and 0.001-10 parts by weight of an alkyl benzoate compound of the following formula (I): wherein each of R1 and R2 is a hydrogen atom, a C1-C8 alkyl or cycloalkyl group, or a C6-C12 aryl, alkylaryl, or arylalkyl group; and R3 is a C1-C30 alkyl group. The interior or exterior trim material of the invention has improved weather resistance and resistance to weather-induced coloring.

  一种汽车内饰或外饰材料，由热塑性弹性体组合物构成，该组合物含有 100 份（按重量计）热塑性弹性体和 0.001-10 份（按重量计）下式（I）的苯甲酸烷基化合物： 其中 R1 和 R2 各为氢原子、C1-C8 烷基或环烷基或 C6-C12 芳基、烷芳基或芳烷基；R3 为 C1-C30 烷基。本发明的内饰或外饰材料具有更好的耐候性和抗风化着色性。
• Lithium aluminium complex hydroxide salt, blending agent for resin and resin composition
  申请人：MIZUSAWA INDUSTRIAL CHEMICALS, LTD.

  公开号：EP0672619B1

  公开（公告）日：1999-06-02
• BENZODIAZEPINE DERIVATIVES, THEIR PREPARATION AND THE THERAPEUTIC USE THEREOF
  申请人：NEURO3D

  公开号：EP1910315A2

  公开（公告）日：2008-04-16