N-[6-(2-benzyloxy-ethoxy)-1H-indazol-3-yl]-4-[methyl-(1-methyl-1-oxy-piperidin-4-yl)-amino]-benzamide | 1409990-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-[6-(2-benzyloxy-ethoxy)-1H-indazol-3-yl]-4-[methyl-(1-methyl-1-oxy-piperidin-4-yl)-amino]-benzamide
• 英文别名: 4-[methyl-(1-methyl-1-oxidopiperidin-1-ium-4-yl)amino]-N-[6-(2-phenylmethoxyethoxy)-1H-indazol-3-yl]benzamide
• CAS: 1409990-17-5
• 化学式: C₃₀H₃₅N₅O₄
• 分子量: 529.639
• InChiKey: ISLIQOVHEDTVJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS<br/>[FR] DÉRIVÉS D'INDAZOLE SUBSTITUÉS ACTIFS EN TANT QU'INHIBITEURS DE KINASES
  申请人：NERVIANO MEDICAL SCIENCES SRL

  公开号：WO2012152763A1

  公开（公告）日：2012-11-15

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及替代吲唑化合物，其调节蛋白激酶的活性，因此在治疗由失调的蛋白激酶活性引起的疾病，如癌症方面具有用处。本发明还提供了制备这些化合物的方法，包括这些化合物的药物组合物，以及利用这些化合物或含有它们的药物组合物治疗疾病的方法。
• SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS
  申请人：Lombardi Borgia Andrea

  公开号：US20140080807A1

  公开（公告）日：2014-03-20

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及取代吲唑化合物，其调节蛋白激酶活性，因此在治疗由失调的蛋白激酶活性引起的疾病，如癌症方面非常有用。本发明还提供制备这些化合物的方法，包括这些化合物的药物组合物，以及利用这些化合物或含有它们的药物组合物治疗疾病的方法。
• Substituted indazole derivatives active as kinase inhibitiors
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US10028934B2

  公开（公告）日：2018-07-24

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.

  本发明涉及取代的吲唑化合物，这些化合物可调节蛋白激酶的活性，因此可用于治疗由蛋白激酶活性降低引起的疾病，如癌症。本发明还提供了制备这些化合物的方法、含有这些化合物的药物组合物，以及利用这些化合物或含有这些化合物的药物组合物治疗疾病的方法。
• SUBSTITUTED INDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITIORS
  申请人：NERVIANO MEDICAL SCIENCES S.R.L.

  公开号：US20160310465A1

  公开（公告）日：2016-10-27

  The present invention relates to substituted indazole compounds which modulate the activity of protein kinases and are therefore useful in treating diseases caused by degulated protein kinase activity, like cancer. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing such these compounds or the pharmaceutical compositions containing them.
• US9408850B2
  申请人：——

  公开号：US9408850B2

  公开（公告）日：2016-08-09