1,3,5-tris[(1R)-2-[3,5-bis[(1R)-1-methoxyethyl]phenyl]-1-phenylmethoxyethyl]benzene | 1036273-21-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1,3,5-tris[(1R)-2-[3,5-bis[(1R)-1-methoxyethyl]phenyl]-1-phenylmethoxyethyl]benzene
• CAS: 1036273-21-8
• 化学式: C₆₉H₈₄O₉
• 分子量: 1057.42
• InChiKey: PXSNBJHXGMELGF-YNRQDDTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.6
• 重原子数：
  78
• 可旋转键数：
  30
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  83.1
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  (R,R)-1,3-bis(1-methoxyethyl)-5-(bromomethyl)benzene 、 alkaline earth salt of/the/ methylsulfuric acid 在 正丁基锂 、 lithium chloride 、 air 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 53.0h， 以52%的产率得到1,3,5-tris[(1R)-2-[3,5-bis[(1R)-1-methoxyethyl]phenyl]-1-phenylmethoxyethyl]benzene
  参考文献：
  名称：

  Synthesis and CD spectroscopy of polyethers with homochiral and heterochiral layers of stereocentres

  摘要：

  Eight polyethers with three to nine stereocentres have been synthesised using chiral base methodology. Examination of the polyethers by CD spectroscopy revealed clear differences between homochiral isomers and isorners with a heterochiral relationship between an 'inner' layer of stereocentres and an outer' layer of stereocentres. A hypothesis to account for these differences has been advanced. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.028

文献信息

• Synthesis and CD spectroscopy of polyethers with homochiral and heterochiral layers of stereocentres
  作者：Alice R.E. Brewer、Alex F. Drake、Susan E. Gibson、Jacob T. Rendell

  DOI：10.1016/j.tet.2008.05.028

  日期：2008.7

  Eight polyethers with three to nine stereocentres have been synthesised using chiral base methodology. Examination of the polyethers by CD spectroscopy revealed clear differences between homochiral isomers and isorners with a heterochiral relationship between an 'inner' layer of stereocentres and an outer' layer of stereocentres. A hypothesis to account for these differences has been advanced. (C) 2008 Elsevier Ltd. All rights reserved.