| 1372157-02-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1372157-02-2
• 化学式: C₂₇H₂₆FN₃O₃
• 分子量: 459.52
• InChiKey: MJIGGRXCYCNULZ-VWLOTQADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.35
• 重原子数：
  34.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  90.37
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  2-(2,4-difluorophenyl)-4,5-dimethyl-1-p-tolyl-1H-imidazole 、 L-酪氨酸 生成
  参考文献：
  名称：

  Luminescent study on the binding interaction of bioactive imidazole with bovine serum albumin—A static quenching mechanism

  摘要：

  Novel bioactive imidazole derivatives were synthesized and characterized by NMR spectra, mass and CHN analysis. The interaction between the imidazole derivative and bovine serum albumin (BSA) was investigated by fluorescence and UV-vis absorption spectroscopy. The fluorescence quenching of BSA by the imidazole derivatives may be due to the formation of imidazole-BSA complex. The fluorescence quenching mechanism of BSA by irnidazole was analyzed and the binding constant has been calculated. The binding distance between imidazole and BSA was obtained based on Forester's non-radiation energy transfer (FRET). The effect of some common ions on the binding constant between imidazole and BSA was also examined. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2011.09.033