2-(tert-butyldimethylsilanyloxy)-1-[2-(tert-butyldimethylsilanyloxy)ethyl]-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]benzene | 1027382-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(tert-butyldimethylsilanyloxy)-1-[2-(tert-butyldimethylsilanyloxy)ethyl]-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]benzene
• 英文别名: 2-(Tert-butyldimethylsilanyloxy)-1-[2-(tert-butyldimethylsilanyloxy)ethyl]-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2,-trichloroethyl]benzene；tert-butyl-[1-[2-[tert-butyl(dimethyl)silyl]oxy-3-[2-[tert-butyl(dimethyl)silyl]oxyethyl]phenyl]-2,2,2-trichloroethoxy]-dimethylsilane
• CAS: 1027382-00-8
• 化学式: C₂₈H₅₃Cl₃O₃Si₃
• 分子量: 628.343
• InChiKey: OPIQHIHWYRXYHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.07
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(tert-butyldimethylsilanyloxy)-1-[2-(tert-butyldimethylsilanyloxy)ethyl]-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]benzene 在 四丁基氟化铵 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以94%的产率得到2-hydroxy-3-(2-hydroxyethyl)benzaldehyde
  参考文献：
  名称：

  tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes

  摘要：

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.072
• 作为产物：
  描述：

  2-{2-(tert-butyldimethylsilanyloxy)-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]phenyl}ethanol 、 叔丁基二甲基氯硅烷 在 咪唑 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以95%的产率得到2-(tert-butyldimethylsilanyloxy)-1-[2-(tert-butyldimethylsilanyloxy)ethyl]-3-[1-(tert-butyldimethylsilanyloxy)-2,2,2-trichloroethyl]benzene
  参考文献：
  名称：

  tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes

  摘要：

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.072

文献信息

• tert-Butyldimethylsilyloxytrichloromethylmethane—readily accessible and robust protecting group for (hetero)aryl aldehydes
  作者：Lauren R. Cafiero、Timothy S. Snowden

  DOI：10.1016/j.tetlet.2008.02.072

  日期：2008.4

  The tert-butyldimethylsilyloxytrichloromethylmethane (TBSTCM) substituent serves as a readily accessible masking group for aromatic and heteroaromatic aldehydes. The TBSTCM substituent is compatible with a range of common reagents and offers several strategic advantages over alternative aldehyde protecting groups. (C) 2008 Elsevier Ltd. All rights reserved.