(E)-diethyl-3,5-dichloroanilinofumarate | 158591-50-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (E)-diethyl-3,5-dichloroanilinofumarate
• 英文别名: diethyl (E)-2-(3,5-dichloroanilino)but-2-enedioate
• CAS: 158591-50-5
• 化学式: C₁₄H₁₅Cl₂NO₄
• 分子量: 332.183
• InChiKey: IXOZGLOTLRZSQI-XYOKQWHBSA-N

物化性质

• 沸点：
  429.0±45.0 °C(predicted)
• 密度：
  1.335±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-二氯苯胺 、 丁炔二酸二乙酯 以 四氢呋喃 为溶剂， 反应 4.0h， 以82%的产率得到(Z)-diethyl-3,5-dichloroanilinofumarate
  参考文献：
  名称：

  WO2007/44682

  摘要：

  公开号：

文献信息

• Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom
  申请人：Lohocla Research Corporation

  公开号：US10875831B1

  公开（公告）日：2020-12-29

  A method for preparing an alkyl 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylate ester is described herein. The method comprises cyclizing a compound of Formula III with Eaton's reagent in heated continuous flow reactor to form a compound of Formula IV wherein in Formula III and Formula IV, each X independently is a halogen atom; and each R independently is C1 to C4 alkyl. Optionally, a cosolvent such as dichloromethane can be included with the Eaton's reagent. A method of preparing a diphenylureido-dihalokynurenic acid alkyl ester of Formula VI from the compound of Formula IV also is described.

  本文介绍了一种制备烷基5,7-二卤代-1,4-二氢-4-氧基喹啉-2-羧酸酯的方法。该方法包括将式III化合物与伊顿试剂在加热的连续流反应器中环化，形成式IV化合物，其中在式III和式IV中，每个X独立地是卤素原子；每个R独立地是C1到C4烷基。可选地，可以在伊顿试剂中包含二氯甲烷等共溶剂。还描述了从式IV化合物制备式VI的二苯基脲基-二卤代基肟酸烷基酯的方法。
• PROCESS FOR PREPARING DIPHENYLUREIDO-DIHALOKYNURENIC ACIDS AND TOSYLATE ADDITION SALTS THEREOF
  申请人：Sengupta Ananya

  公开号：US20220162168A1

  公开（公告）日：2022-05-26

  A method of preparing 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylic acid tosylate addition salts is provided, which involves direct conversion of esters of Formula V as described herein to acids of Formula VIII as described herein. Tosylate addition salts of Formula IX as described herein are then prepared from the acids of Formula VIII.
• [EN] PROCESS FOR PREPARING 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLATES AND 4-AMINOQUINOLINE COMPOUNDS THEREFROM<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 1,4-DIHYDRO-4-OXOQUINOLINE-2-CARBOXYLATES ET DE COMPOSÉS DE 4-AMINOQUINOLINE À PARTIR DE CEUX-CI
  申请人：LOHOCLA RES CORPORATION

  公开号：WO2021030511A1

  公开（公告）日：2021-02-18

  A method for preparing an alkyl 5,7-dihalo-1,4-dihyro-4-oxoquinoline-2-carboxylate ester is described herein.