(4-羟基-3,5-二碘-苯基)-乙酸酰胺 | 100130-56-1

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (4-羟基-3,5-二碘-苯基)-乙酸酰胺
• 英文名称: (4-hydroxy-3,5-diiodo-phenyl)-acetic acid amide
• 英文别名: (4-Hydroxy-3,5-dijod-phenyl)-essigsaeure-amid；2-(4-Hydroxy-3,5-diiodophenyl)acetamide
• CAS: 100130-56-1
• 化学式: C₈H₇I₂NO₂
• 分子量: 402.958
• InChiKey: FHIZLPYEGNABSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-羟基-3,5-二碘苯乙酸 在 氯化亚砜 作用下， 生成 (4-羟基-3,5-二碘-苯基)-乙酸酰胺
  参考文献：
  名称：

  The role of gender and family support on dietary compliance in an African American adolescent hypertension prevention study

  摘要：

  Social support experiences vary markedly across gender groups, and little is known about the role of social support in promoting healthy dietary compliance in African American adolescents who are at increased risk for developing hypertension. This study examined the relation between gender dietary social support, and compliance to a low sodium diet. Casual blood pressures were also examined in relation to dietary compliance and gender One hundred eighty-four healthy African American adolescents (83 boys, 101 girls) participated in an intensive 5-day low sodium diet (50 mEq/24 hr) as part of a hypertension prevention program. Emotional dietary social support from family members and friends was measured at baseline. Compliance was defined as urinary sodium excretion of less than or equal to 50 mEq/24 hr at postsodium restriction. The results indicated a significant Gender x Compliance effect for positive family support (p < .05). Girls who were compliant reported higher levels of dietary support from family members (19.2 +/- 7.8) than boys who were compliant (16.9 +/- 7.0). In contrast, boys who were compliant reported lower levels of dietary support from family members (16.9 +/- 7.0) than boys who were not compliant (20.2 +/- 7.5). Systolic blood pressure showed a trend toward decreasing in compliant participants (104.4 +/- 8.4 vs. 101.7 +/- 8.0, mm Hg, p < .06), but the effect diminished when Quetelet Index (kg/m(2)) was controlled for in the analyses (p < .12). These results suggest that higher levels of emotional dietary support from family members are associated with better adherence to short-term sodium restriction for African American girls as compared to boys. Further research is needed to determine the long-term impact of social support on sodium restriction in adolescent populations.

  DOI：

  10.1207/s15324796abm2301_9

文献信息

• 7-Deazapurine derivatives
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0075881A1

  公开（公告）日：1983-04-06

  Novel 7-deazapurine derivatives of the formula: wherein X is halogen, Y is hydroxyl or di-C1-3 alkylamino, Z is a -NH- or -NHC(=NH)- group, ℓ is an integer of 1 to 5, m is an integer of 0 to 2, and n is 1 when Z is a -NH- group or n is 0 or 1 when Z is a -NHC(=NH)- group, and salts thereof are selectively taken up by tumor cells.

  式中 X 为卤素，Y 为羟基或二-C1-3 烷基氨基，Z 为 -NH- 或 -NHC(=NH)- 基团，ℓ 为 1 至 5 的整数，m 为 0 至 2 的整数，当 Z 为 -NH- 基团时，n 为 1；当 Z 为 -NHC(=NH)- 基团时，n 为 0 或 1。
• US4435570A
  申请人：——

  公开号：US4435570A

  公开（公告）日：1984-03-06