| 1526931-27-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• CAS: 1526931-27-0
• 化学式: C₂₃H₂₂N₂O
• 分子量: 342.44
• InChiKey: XQFSOPCWVKIPGY-FYYLOGMGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.74
• 重原子数：
  26.0
• 可旋转键数：
  2.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  23.55
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  在 盐酸羟胺 作用下， 以 甲醇 、 水 为溶剂， 反应 21.5h， 以99%的产率得到(R)-2-methyl-N-phenylpyrrolidine-2-carboxamide
  参考文献：
  名称：

  Complementary Stereochemical Outcomes in Proline-Based Self-Regenerations of Stereocenters

  摘要：

  Stereoselective alkylations of proline-based amino amides are described, where high levels of either a cis or trans configuration can be attained simply by the choice of the aminal group. Isobutryaldehyde-derived aminals provide the cis configuration, while 1-naphthaldehyde-derived aminals engender the complementary trans configuration.

  DOI：

  10.1021/ol403320d
• 作为产物：
  描述：

  (S)-n-苯基-2-吡咯烷羧酰胺 在 magnesium sulfate 、 溶剂黄146 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 、 甲苯 为溶剂， 反应 1.17h， 生成 、
  参考文献：
  名称：

  An analysis of the complementary stereoselective alkylations of imidazolidinone derivatives toward α-quaternary proline-based amino amides

  摘要：

  Alkylations of praline-based imidazolidinones are described based on the principle of self-regeneration of stereocenters (SRS), affording high levels of either the cis or trans configured products. Stereoselectivity is dictated solely on the nature of the 'temporary' group, where isobutyraldehyde-derived imidazolidinones provide the cis configured products and 1-naphthaldehyde-derived imidazolidinones afford the complementary trans configured products. These stereodivergent products can be readily cleaved to afford both alpha-alkylated proline enantiomers from readily available L-proline. A series of imidazolidinones were alkylated to investigate the origin of the anti-selectivity. Potential contributions toward the observed anti-selectivity are discussed on the basis of these experiments, suggesting a refined hypothesis for selectivity may be in order. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.05.010