2(S)-{[(4-methylphenyl)sulfonyl]amino}-3-sulfanylpropanoic acid | 1523416-40-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2(S)-{[(4-methylphenyl)sulfonyl]amino}-3-sulfanylpropanoic acid
• CAS: 1523416-40-1
• 化学式: C₁₀H₁₃NO₄S₂
• 分子量: 275.35
• InChiKey: MVNMLVQCWNISLC-SECBINFHSA-N

反应信息

• 作为产物：
  描述：

  D-cysteine 、 对甲苯磺酰氯 在 sodium hydroxide 作用下， 以 水 为溶剂， 以75%的产率得到2(S)-{[(4-methylphenyl)sulfonyl]amino}-3-sulfanylpropanoic acid
  参考文献：
  名称：

  Development of amino acid conjugated sulfonamides as potent antiulcer agent

  摘要：

  A series of 2-{[(4-methylphenyl) sulfonyl] amino}-3-sulfanylpropanoic acid (1a) and its analogs 1b-j have been synthesized. These compounds were screened for their in vivo efficacy in pyloric ligation model. Compounds 1a and 1b with higher antiulcer potential were further screened in other gastric models to explore the mode of antiulcer action. To further understand the mode of action, in vitro inhibition of H+/K+ ATPase activity in gastric microsome isolated from rat stomach was studied. This was rationalized by in silico experiments.

  DOI：

  10.1007/s00044-013-0891-y