4-(2-氯-丙基)-吗啉 | 41821-45-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-(2-氯-丙基)-吗啉
• 英文名称: 4-(2-chloro-propyl)-morpholine
• 英文别名: 4-(2-Chlor-propyl)-morpholin；(+/-)-4-(2-Chlor-propyl)-morpholin；1-Morpholino-2-chlor-propan；4-(2-Chloropropyl)morpholine
• CAS: 41821-45-8
• 化学式: C₇H₁₄ClNO
• 分子量: 163.647
• InChiKey: DRWDYJVXXHLJLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  99-100 °C(Press: 20 Torr)
• 密度：
  1.059±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(2-氯-丙基)-吗啉 在 sodium amide 、 甲苯 、 苯 作用下， 生成 苯吗庚酮
  参考文献：
  名称：

  Bockmuehl; Ehrhart, Justus Liebigs Annalen der Chemie, 1949, vol. 561, p. 52,76

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 氯仿 作用下， 生成 4-(2-氯-丙基)-吗啉
  参考文献：
  名称：

  Dahlbom, Acta Chemica Scandinavica (1947), 1949, vol. 3, p. 247,254

  摘要：

  DOI：

文献信息

• Electrochemical fluorination of aminoalkyl ethers
  作者：G.G.I. Moore、J.C. Hansen、T.M. Barrett、J.E. Waddell、K.M. Jewell、T.A. Kestner、R.M. Payfer

  DOI：10.1016/s0022-1139(00)80506-0

  日期：1986.6

  trialkylamines in liquid HF takes place readily in good yields, whereas dialkyl ethers give low yields. The latter fluorinated ethers are of interest for their low temperature properties. Our goal in this work was to prepare fluorinated aminoalkyl ether fluids which might combine the favorable yields of amines and properties of ethers. Several dialkylamine and alkylene units were combined in a variety of diamino

  已知在液体HF中三烷基胺的电化学氟化容易以良好的产率发生，而二烷基醚的产率很低。后者的氟化醚因其低温性能而受到关注。我们在这项工作中的目标是制备氟化的氨基烷基醚流体，该流体可以结合胺的良好收率和醚的性能。将几种二烷基胺和亚烷基单元结合在各种二氨基单醚，二氨基二醚和单氨基单醚中。在第一类材料中，电化学氟化产率高达50％。描述了这些新流体的结构-屈服关系和性质。
• Benzopyrano(3,4-C)pyridine bronchodilators
  申请人：Warner-Lambert Company

  公开号：US03961057A1

  公开（公告）日：1976-06-01

  Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##SPC1## In the above formula, R.sub.1 and R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c]pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

  披萨酱油是一种以番茄酱为基础的调味料，通常用于披萨上。它的配方可以包括番茄、大蒜、洋葱、香草和其他香料。披萨酱油可以买到现成的，也可以自己制作。
• Substituted benzopyrano[3,4-c]pyridines and process for their preparation
  申请人：Warner-Lambert Company

  公开号：US04013671A1

  公开（公告）日：1977-03-22

  Substituted benzopyrano[3,4-c]pyridines having the following structural formula are disclosed: ##STR1## In the above formula, R.sub.1 R.sub.2 are hydrogen, a hydroxyl group or a lower alkoxyl group of from 1 to 6 carbon atoms; R.sub.3 is hydrogen or a lower alkyl group of from 1 to 6 carbon atoms and X is an oxygen atom, a sulfur atom, a methylene group or a nitrogen atom substituted by hydrogen, a lower alkyl group of from 1 to 6 carbon atoms or a lower alkanoyl group of from 1 to 6 carbon atoms. The compounds of this invention are prepared by reacting an R.sub.1, R.sub.2 -substituted phenol with a 3-carbethoxy-4-piperidone in the presence of an acid catalyst to give an intermediate R.sub.1, R.sub.2 -substituted benzopyrano[3,4-c] pyridine. N-aminoalkylbenzopyrano[3,4-c]pyridines are obtained by treating the benzopyrano[3,4-c]pyridine with an appropriately substituted alkyl halide. The compounds of this invention are useful as bronchodilators for the treatment of bronchial asthma.

  本发明揭示了具有以下结构式的取代苯并吡喃[3,4-c]吡啶：##STR1## 在上述公式中，R.sub.1 R.sub.2是氢、羟基或1至6个碳原子的低烷氧基；R.sub.3是氢或1至6个碳原子的低烷基；X是氧原子、硫原子、亚甲基或氮原子，被氢、1至6个碳原子的低烷基或1至6个碳原子的低烷酰基取代。本发明的化合物是通过在酸催化剂存在下将R.sub.1，R.sub.2-取代苯酚与3-羰基-4-哌啶酮反应，得到中间体R.sub.1，R.sub.2-取代苯并吡喃[3,4-c]吡啶而制备的。通过用适当取代的烷基卤代物处理苯并吡喃[3,4-c]吡啶，可以获得N-氨基烷基苯并吡喃[3,4-c]吡啶。本发明的化合物可用作支气管扩张剂，用于治疗支气管哮喘。
• Rapidly immobilizing paper coating compositions
  申请人：National Starch and Chemical Investment Holding Corporation

  公开号：EP0426987A1

  公开（公告）日：1991-05-15

  Rapidly immobilizing paper coating compositions may be prepared by formulating an aqueous coating composition comprising a cationic starch, pigment and sufficient base to obtain a pH above the pK of the starch derivative so that the starch is no longer cationic; coating the paper substrate; and lowering the pH of the coating such that the starch becomes cationic.

  快速固定纸张涂层组合物的制备方法是：配制一种水性涂层组合物，其中包括阳离子淀粉、颜料和足够的碱，以获得高于淀粉衍生物 pK 的 pH 值，从而使淀粉不再是阳离子；涂布纸基材；然后降低涂层的 pH 值，使淀粉变成阳离子。
• HIV protease inhibitors useful for the treatment of aids
  申请人：MERCK & CO. INC.

  公开号：EP0434365A2

  公开（公告）日：1991-06-26

  Compounds of the form, A-G-B-B-J wherein A is an amine protecting group or urethane, G a dipeptide isostere substituted with a basic amine nitrogen, B an amino acid or analog thereof, and J a small terminal group are described. These compounds are useful in the inhibition of HIV protease, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

  A-G-B-B-J 形式的化合物 其中 A 是胺保护基团或氨基甲酸乙酯，G 是被碱性胺氮取代的二肽异构体，B 是氨基酸或其类似物，J 是小的末端基团。这些化合物作为化合物、药学上可接受的盐、药物组合成分，无论是否与其他抗病毒药物、免疫调节剂、抗生素或疫苗结合使用，都可用于抑制 HIV 蛋白酶、预防或治疗 HIV 感染和治疗 AIDS。还描述了治疗艾滋病的方法和预防或治疗艾滋病毒感染的方法。